IL5 靶点信息

IL5 分子靶点信息概述

  • 分子名：IL5, interleukin 5
  • 基因家族：Interleukins
  • 别名：IL-5; EDF; TRF
  • 全称：interleukin-5; T-cell replacing factor; B cell differentiation factor I; eosinophil differentiation factor; colony-stimulating factor, eosinophil; interleukin 5 (colony-stimulating factor, eosinophil)

IL5 分子靶点综述

白细胞介素5(IL-5)是造血家族Th2细胞因子成员，由115个氨基酸组成。与该细胞因子家族其它成员(IL-3和GM-CSF)不同，该糖蛋白的活化形式是同源二聚体。IL-5由Th2细胞和肥大细胞分泌。它对B细胞以及其它类型的细胞产生的生物学活性表明，IL-5对Th2细胞的活性具有重要的功能性作用。IL-5通过与其受体结合，刺激B细胞生长，提高免疫球蛋白分泌。它也是活化嗜酸性粒细胞的关键因子。IL-5一直以来与多种变态疾病相关，包括变应性鼻炎和哮喘，在循环组织、气管组织中观察到大幅增加的IL-5，而痰嗜酸性粒细胞则减少。

IL5, interleukin 5 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL5 分子靶点信息

  • 分子名：IL5, interleukin 5
  • 别称：
    • B cell differentiation factor I
    • B-cell differentiation factor I
    • colony-stimulating factor, eosinophil
    • EDF
    • eosinophil differentiation factor
    • IL-5
    • interleukin-5
    • T-cell replacing factor
    • TRF
  • 基因序列：NCBI_Gene: 3567
  • 蛋白序列：UniProtKB: P05113

人 Human IL5靶点分子功能（预测）

Predicted to enable cytokine activity; growth factor activity; and interleukin-5 receptor binding activity. Involved in positive regulation of podosome assembly. Located in extracellular region. Implicated in asthma. Biomarker of several diseases, including Churg-Strauss syndrome; Henoch-Schoenlein purpura; arthritis (multiple); asthma (multiple); and lymphoid leukemia (multiple).

小鼠 Mouse Il5 分子靶点信息

小鼠 Mouse Il5 靶点分子功能（预测）

Enables cytokine activity. Involved in positive regulation of DNA-binding transcription factor activity; positive regulation of immunoglobulin production; and positive regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in colon; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5).

大鼠 Rat Il5 分子靶点信息

  • 分子名：Il5, interleukin 5
  • 别称：
    • B-cell growth factor II
    • BCGF-II
    • cytotoxic T-lymphocyte inducer
    • eosinophil differentiation factor
    • IL-5
    • Interleukin 5 (colony-stimulating factor eosinophil)
    • Interleukin 5 (colony-stimulating factor, eosinophil)
    • interleukin-5
    • T-cell replacing factor
    • TRF
  • 基因序列：NCBI_Gene: 24497
  • 蛋白序列：

大鼠 Rat Il5 靶点分子功能（预测）

Enables cytokine activity and interleukin-5 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of eosinophil differentiation; and positive regulation of receptor signaling pathway via JAK-STAT. Located in extracellular space. Used to study asthma. Biomarker of several diseases, including allergic rhinitis; esophageal cancer; middle cerebral artery infarction; peptic esophagitis; and prostatic hypertrophy. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5 (interleukin 5).

IL5 分子产品列表

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