IL3 靶点信息

IL3 分子靶点信息概述

  • 分子名：IL3, interleukin 3
  • 基因家族：Interleukins
  • 别名：IL-3; MULTI-CSF; MCGF; MGC79398; MGC79399
  • 全称：multilineage-colony-stimulating factor; hematopoietic growth factor; P-cell stimulating factor; mast-cell growth factor; colony-stimulating factor, multiple; interleukin 3 (colony-stimulating factor, multiple)

IL3 分子靶点综述

白细胞介素3(IL-3)在人类中由IL3基因编码。它是一种生物信号(细胞因子)，可作为免疫系统的一部分来提高机体对疾病的先天免疫应答。它是由嗜碱性粒细胞和活化的T细胞分泌产生，在免疫应答中可协助骨髓来源的T细胞生长和分化。IL-3通过结合IL-3受体起作用，可刺激多能造血干细胞分化为髓系祖细胞，或与IL-7一起，刺激多能造血干细胞分化为淋巴系祖细胞。另外，IL-3与其它细胞因子，如促红细胞生成素(EPO)、粒细胞巨噬细胞集落刺激因子(GM-CSF)和IL-6一起刺激髓系的所有细胞(粒细胞、单核细胞和树突状细胞)增殖。

IL3, interleukin 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL3 分子靶点信息

  • 分子名：IL3, interleukin 3
  • 别称：
    • colony-stimulating factor, multiple
    • hematopoietic growth factor
    • IL-3
    • interleukin-3
    • mast cell growth factor
    • mast-cell growth factor
    • MCGF
    • MGC79398
    • MGC79399
    • MULTI-CSF
    • multilineage-colony-stimulating factor
    • multipotential colony-stimulating factor
    • P-cell stimulating factor
    • P-cell-stimulating factor
  • 基因序列：NCBI_Gene: 3562
  • 蛋白序列：UniProtKB: P08700

人 Human IL3靶点分子功能（预测）

Predicted to enable interleukin-3 receptor binding activity. Involved in embryonic hemopoiesis; positive regulation of cell population proliferation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Implicated in Graves' disease; asthma; and rheumatoid arthritis. Biomarker of several diseases, including Ebola hemorrhagic fever; genital herpes; major depressive disorder; obesity; and psoriasis.

小鼠 Mouse Il3 分子靶点信息

小鼠 Mouse Il3 靶点分子功能（预测）

Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; monocyte differentiation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in skin; stomach; thymus; and vascular system. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3).

大鼠 Rat Il3 分子靶点信息

大鼠 Rat Il3 靶点分子功能（预测）

Enables cytokine activity and interleukin-3 receptor binding activity. Involved in several processes, including hemopoiesis; positive regulation of cell population proliferation; and regulation of cell growth. Located in extracellular space. Used to study osteosarcoma. Biomarker of prostatic hypertrophy and pyelonephritis. Human ortholog(s) of this gene implicated in Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3).

IL3 分子产品列表

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