IL2RA 靶点信息

IL2RA 分子靶点信息概述

  • 分子名：IL2RA, interleukin 2 receptor subunit alpha
  • 基因家族：CD molecules; Interleukin receptors; Sushi domain containing
  • 别名：CD25
  • 曾用名：IL2R; IDDM10
  • 全称：insulin-dependent diabetes mellitus 10; interleukin 2 receptor, alpha

IL2RA 分子靶点综述

白细胞介素2受体(IL-2R)是一种在某些免疫细胞如淋巴细胞表面表达的异源三聚体蛋白，它可结合和应答细胞因子IL-2。IL-2R由三条链组成：一条α链(IL-2Rα/CD25)、一条β链(IL-2Rβ/CD122)和一条γ链(IL-2Rγ/CD132)。其中α链低亲和结合IL-2，而β和γ链组成的复合物中等亲和结合IL-2。IL-2及其受体主要通过直接作用于T细胞，从而在免疫系统、耐受性和免疫力中发挥重要作用。但是可溶性IL-2Rα(sIL-2Rα)的功能未知，因为它的低亲和力抑制了IL-2的结合。在任何情况下，体液中升高的sIL-2Rα水平与T、B细胞活化增加和免疫系统激活相关。监测血清中sIL-2Rα水平为一些病理状态如类风湿性关节炎、系统性红斑狼疮(SLE)、某些白血病和淋巴瘤提供更详细的见解。

IL2RA, interleukin 2 receptor subunit alpha 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL2RA 分子靶点信息

  • 分子名：IL2RA, interleukin 2 receptor subunit alpha
  • 别称：
    • CD25
    • IDDM10
    • IL-2 receptor subunit alpha
    • IL-2-RA
    • IL-2R subunit alpha
    • IL2-RA
    • IL2R
    • IMD41
    • insulin-dependent diabetes mellitus 10
    • interleukin 2 receptor, alpha
    • interleukin 2 receptor, alpha chain
    • interleukin-2 receptor subunit alpha
    • p55
    • TAC antigen
    • TCGFR
  • 基因序列：NCBI_Gene: 3559
  • 蛋白序列：UniProtKB: P01589

人 Human IL2RA靶点分子功能（预测）

Contributes to interleukin-2 receptor activity. Involved in regulation of T cell tolerance induction. Predicted to be located in plasma membrane. Predicted to be part of interleukin-2 receptor complex. Implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Biomarker of COVID-19; Hantavirus hemorrhagic fever with renal syndrome; and idiopathic pulmonary fibrosis.

小鼠 Mouse Il2ra 分子靶点信息

小鼠 Mouse Il2ra 靶点分子功能（预测）

Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha).

大鼠 Rat Il2ra 分子靶点信息

  • 分子名：Il2ra, interleukin 2 receptor subunit alpha
  • 别称：
    • IL-2 receptor alpha subunit
    • IL-2 receptor subunit alpha
    • IL-2-RA
    • IL-2R subunit alpha
    • IL2-RA
    • IL2RAC
    • interleukin 2 receptor, alpha
    • interleukin 2 receptor, alpha chain
    • interleukin-2 receptor alpha chain
    • interleukin-2 receptor subunit alpha
  • 基因序列：NCBI_Gene: 25704
  • 蛋白序列：UniProtKB: P26897

大鼠 Rat Il2ra 靶点分子功能（预测）

Enables interleukin-2 receptor activity. Involved in inflammatory response to antigenic stimulus; positive regulation of T cell differentiation; and positive regulation of T cell proliferation. Located in cell surface. Used to study Korean hemorrhagic fever; asthma; and diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha).

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