IL23A 靶点信息

IL23A 分子靶点信息概述

  • 分子名：IL23A, interleukin 23 subunit alpha
  • 基因家族：Interleukins
  • 别名：SGRF; IL23P19; IL-23; IL-23A; P19
  • 全称：interleukin-six, G-CSF related factor; interleukin 23, alpha subunit p19

IL23A 分子靶点综述

白细胞介素23(IL-23)是一种由IL-12p40亚基和IL-23p19亚基组成的异二聚体细胞因子，其中p40亚基是IL-23与IL-12共用的。IL-23的功能性受体已被鉴定，由IL-12Rβ1和IL-23R组成。IL-23在1型极化T细胞的免疫应答中起作用。虽然IL-12可强有力激活幼稚T细胞，但是最初的报道认为IL-23可优先作用于记忆T细胞，促进其分泌IFN-γ和增殖，这表明IL-23在控制细菌感染上有重要作用。IL-23被进一步描述为是一种控制周围组织炎症的关键细胞因子。p19的过表达与多个器官以及包含皮肤在内的上皮组织的炎症有关。IL-23参与中枢神经系统和自身免疫性疾病的炎症。

IL23A, interleukin 23 subunit alpha 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL23A 分子靶点信息

  • 分子名：IL23A, interleukin 23 subunit alpha
  • 别称：
    • IL-23
    • IL-23 subunit alpha
    • IL-23-A
    • IL-23A
    • IL-23p19
    • IL23P19
    • interleukin 23 p19 subunit
    • interleukin 23, alpha subunit p19
    • interleukin-23 subunit alpha
    • interleukin-23 subunit p19
    • interleukin-six, G-CSF related factor
    • JKA3 induced upon T-cell activation
    • MGC79388
    • P19
    • SGRF
  • 基因序列：NCBI_Gene: 51561
  • 蛋白序列：UniProtKB: Q9NPF7

人 Human IL23A靶点分子功能（预测）

Contributes to interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Part of interleukin-23 complex.

小鼠 Mouse Il23a 分子靶点信息

小鼠 Mouse Il23a 靶点分子功能（预测）

Contributes to interleukin-23 receptor binding activity. Involved in positive regulation of defense response to virus by host; positive regulation of immune response; and positive regulation of neutrophil chemotaxis. Acts upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Part of interleukin-23 complex. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL23A (interleukin 23 subunit alpha).

大鼠 Rat Il23a 分子靶点信息

  • 分子名：Il23a, interleukin 23 subunit alpha
  • 别称：
    • IL-23 subunit alpha
    • IL-23-A
    • IL-23p19
    • Interleukin 23, alpha subunit p19
    • interleukin-23 subunit alpha
    • interleukin-23 subunit p19
    • MGC114275
  • 基因序列：NCBI_Gene: 155140
  • 蛋白序列：UniProtKB: Q91Z84

大鼠 Rat Il23a 靶点分子功能（预测）

Predicted to enable cytokine activity. Predicted to contribute to interleukin-23 receptor binding activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte activation; and positive regulation of peptidyl-tyrosine phosphorylation. Predicted to act upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Predicted to be part of interleukin-23 complex. Orthologous to human IL23A (interleukin 23 subunit alpha).

IL23A 分子产品列表

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