IL16 靶点信息

IL16 分子靶点信息概述

  • 分子名：IL16, interleukin 16
  • 基因家族：Interleukins; PDZ domain containing
  • 别名：LCF; IL-16; prIL-16; HsT19289; FLJ42735; FLJ16806
  • 全称：prointerleukin 16; lymphocyte chemoattractant factor; interleukin 16 (lymphocyte chemoattractant factor)

IL16 分子靶点综述

白细胞介素16(IL-16)是由多种细胞(包括淋巴细胞和一些上皮细胞)释放的细胞因子，是特定表达细胞表面分子CD4的免疫细胞的趋化物。IL-16最初被描述为是一种可吸引人类中活化的T细胞的因子，以前称之为淋巴细胞趋化因子(LCF)。此后，研究证明IL-16可招募和激活许多其它表达CD4分子的细胞，包括单核细胞、嗜酸性粒细胞和树突状细胞。该基因编码的蛋白是一种多效细胞因子，可作为趋化因子、T细胞活化的调节剂和HIV复制的抑制剂。这种细胞因子的信号过程受CD4调节。IL-16的表达与哮喘、类风湿性关节炎、系统性红斑狼疮、溃疡性结肠炎、过敏性皮炎和多发性硬化症的炎症过程有关。例如，IL-16的表达与哮喘上皮中浸润的CD4+T细胞的数量直接相关。

IL16, interleukin 16 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL16 分子靶点信息

  • 分子名：IL16, interleukin 16
  • 别称：
    • FLJ16806
    • FLJ42735
    • FLJ44234
    • HsT19289
    • IL-16
    • LCF
    • lymphocyte chemoattractant factor
    • neuronal interleukin 16
    • NIL16
    • prIL-16
    • PRIL16
    • pro-interleukin-16
    • prointerleukin 16
  • 基因序列：NCBI_Gene: 3603
  • 蛋白序列：UniProtKB: Q14005

人 Human IL16靶点分子功能（预测）

Enables CD4 receptor binding activity. Involved in positive regulation of cytokine production; positive regulation of inflammatory response; and regulation of calcium ion transport. Located in several cellular components, including Flemming body; focal adhesion; and nuclear speck. Implicated in asthma and prostate cancer. Biomarker of asthma; chronic fatigue syndrome; chronic obstructive pulmonary disease; malignant astrocytoma; and rhinitis.

小鼠 Mouse Il16 分子靶点信息

小鼠 Mouse Il16 靶点分子功能（预测）

Enables cytokine activity. Involved in cytokine-mediated signaling pathway. Acts upstream of or within several processes, including induction of positive chemotaxis; positive regulation of chemokine production; and positive regulation of neutrophil activation. Located in collagen-containing extracellular matrix. Is expressed in several structures, including foregut; jaw; limb; respiratory system; and vibrissa. Human ortholog(s) of this gene implicated in asthma and prostate cancer. Orthologous to human IL16 (interleukin 16).

大鼠 Rat Il16 分子靶点信息

大鼠 Rat Il16 靶点分子功能（预测）

Predicted to enable CD4 receptor binding activity and cytokine activity. Predicted to be involved in several processes, including induction of positive chemotaxis; leukocyte chemotaxis; and positive regulation of cytokine production. Predicted to act upstream of or within positive regulation of chemokine production and positive regulation of neutrophil activation. Predicted to be located in several cellular components, including Flemming body; focal adhesion; and nuclear speck. Biomarker of borna disease; glioblastoma; and periodontal disease. Human ortholog(s) of this gene implicated in asthma and prostate cancer. Orthologous to human IL16 (interleukin 16).

IL16 分子产品列表

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