文章目录[隐藏]
IL15RA 分子靶点信息概述
- 分子名：IL15RA, interleukin 15 receptor subunit alpha
- 基因家族：CD molecules
- 别名：CD215, IL-15RA
IL15RA/CD215 分子靶点综述
白细胞介素 15 (IL-15)是一种促炎性蛋白，在中性粒细胞、树突状细胞和巨噬细胞的活化中起作用，对于 NK 细胞和CD8+ T 细胞的发育和生存是必不可少的。IL-15 通过异三聚体受体信号激活 Jak/Stat 途径。虽然 IL-15 mRNA 在许多细胞类型中表达，但是该分泌蛋白在生物样品中很少检测得到。最近的研究表明，IL-15 滞留在胞内，只有当与其唯一的受体 IL-15Rα 形成复合物才能分泌到胞外。可溶性 IL-15/IL-15R 复合物由小鼠树突状细胞、成纤维细胞和巨噬细胞产生，它的结合活性比单独的 IL-15 提高 10 - 100 倍。
IL15RA, interleukin 15 receptor subunit alpha 分子靶点种属信息
人 Human IL15RA/CD215 分子靶点信息
- 分子名：IL15RA, interleukin 15 receptor subunit alpha
- 别称：
- CD215
- interleukin 15 receptor alpha isoform EM2
- interleukin 15 receptor alpha isoform IC2
- interleukin 15 receptor alpha isoform IC3
- interleukin 15 receptor alpha isoform IC4
- interleukin 15 receptor alpha isoform IC5
- interleukin 15 receptor alpha isoform IC6
- interleukin 15 receptor alpha isoform IC7
- interleukin 15 receptor alpha isoform IC8
- interleukin 15 receptor, alpha
- interleukin-15 receptor subunit alpha
- MGC104179
- 基因序列：NCBI_Gene: 3601
- 蛋白序列：UniProtKB: P13261
人 Human IL15RA/CD215 靶点分子功能（预测）
Enables interleukin-15 receptor activity and protein kinase binding activity. Involved in interleukin-15-mediated signaling pathway and positive regulation of phagocytosis. Located in cell surface. Biomarker of hepatocellular carcinoma.
小鼠 Mouse Il15ra 分子靶点信息
- 分子名：Il15ra, interleukin 15 receptor, alpha chain
- 别称：
- AA690181
- expressed sequence AA690181
- 基因序列：NCBI_Gene: 16169
- 蛋白序列：
小鼠 Mouse Il15ra 靶点分子功能（预测）
Predicted to enable interleukin-15 receptor activity and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell differentiation. Located in cytoplasmic vesicle. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human IL15RA (interleukin 15 receptor subunit alpha).
大鼠 Rat Il15ra 分子靶点信息
- 分子名：Il15ra, interleukin 15 receptor subunit alpha
- 别称：
- interleukin 15 receptor alpha chain
- interleukin 15 receptor, alpha
- interleukin 15 receptor, alpha chain
- interleukin-15 receptor alpha chain
- interleukin-15 receptor subunit alpha
- LOC364775
- LOC502145
- LOC690369
- similar to Interleukin-15 receptor alpha chain precursor (IL-15R-alpha) (IL-15RA)
- 基因序列：NCBI_Gene: 690369
- 蛋白序列：
大鼠 Rat Il15ra 靶点分子功能（预测）
Predicted to enable interleukin-15 receptor activity and protein kinase binding activity. Involved in negative regulation of neuron projection development; receptor signaling pathway via JAK-STAT; and response to nutrient levels. Predicted to be located in cell surface; cytoplasmic vesicle; and plasma membrane. Orthologous to human IL15RA (interleukin 15 receptor subunit alpha).
