IL13 靶点信息

IL13 分子靶点信息概述

  • 分子名：IL13, interleukin 13
  • 基因家族：Interleukins
  • 别名：P600; IL-13; ALRH; BHR1; MGC116786; MGC116788; MGC116789
  • 全称：allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma)

IL13 分子靶点综述

白细胞介素13(IL-13)位于染色体5q31上，与IL-4具有30%的同源性和相似的结构。IL-13由许多细胞类型分泌产生，尤其是2型辅助性T细胞(Th2)。与密切相关的IL-4相似，IL-13对免疫细胞也具有多种功能。虽然IL-13主要与气道疾病的诱导相关，但是它还具有消炎特性。IL-13可诱导造血细胞的变化，但是这些效果与IL-4相比可能不那么重要。IL-13专门诱导寄生感染的器官的生理变化。它也可诱导过敏性肺部疾病的许多特征，包括气道高反应性、杯状细胞增殖和黏液高分泌，这些都会导致气道阻塞。此外，IL-13抑制原代培养衍生的巨噬细胞中HIV-1的复制，可作为体内单核细胞和巨噬细胞中抑制HIV感染的候选细胞因子。

IL13, interleukin 13 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IL13 分子靶点信息

  • 分子名：IL13, interleukin 13
  • 别称：
    • allergic rhinitis
    • ALRH
    • BHR1
    • Bronchial hyperresponsiveness-1 (bronchial asthma)
    • IL-13
    • interleukin-13
    • MGC116786
    • MGC116788
    • MGC116789
    • P600
  • 基因序列：NCBI_Gene: 3596
  • 蛋白序列：UniProtKB: P35225

人 Human IL13靶点分子功能（预测）

Predicted to enable cytokine activity and interleukin-13 receptor binding activity. Involved in several processes, including negative regulation of complement-dependent cytotoxicity; negative regulation of endothelial cell apoptotic process; and positive regulation of interleukin-10 production. Located in extracellular region. Implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Biomarker of several diseases, including Plasmodium falciparum malaria; autoimmune disease (multiple); cystic fibrosis; lung disease (multiple); and scleroderma (multiple).

小鼠 Mouse Il13 分子靶点信息

小鼠 Mouse Il13 靶点分子功能（预测）

Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13).

大鼠 Rat Il13 分子靶点信息

大鼠 Rat Il13 靶点分子功能（预测）

Enables interleukin-13 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of cation transmembrane transport. Located in extracellular space. Used to study asthma; extrinsic allergic alveolitis; and lipoid nephrosis. Biomarker of several diseases, including alcoholic hepatitis; middle cerebral artery infarction; peptic esophagitis; prostatic hypertrophy; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13).

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