IGFBP4 靶点信息

IGFBP4 分子靶点信息概述

  • 分子名：IGFBP4, insulin like growth factor binding protein 4
  • 基因家族：Insulin like growth factor binding proteins
  • 别名：IBP4; BP-4; HT29-IGFBP; IGFBP-4
  • 全称：IGF-binding protein 4; insulin-like growth factor-binding protein 4; insulin-like growth factor binding protein 4

IGFBP4 分子靶点综述

胰岛素样生长因子结合蛋白 4(IGFBP4)是一个 24 kDa 的蛋白质，该蛋白结合胰岛素样生长因子(IGFs) I 和 II，并以糖基化和非糖基化的形式在血浆中循环。该结合延长了 IGFs 的半衰期，并 改变了它们与细胞表面受体的相互作用。 胰岛素样生长因子(IGF)结合蛋白超家族包括六个高亲和力的 IGF 结合蛋白(IGFBP)，以及至少四 个称为 IGFBP 相关蛋白(IGFBP-RP)的低亲和力结合蛋白。IGFBP-4 在体外抑制 IGF-I 的作用，是 啮齿动物动脉壁中最丰富的胰岛素样生长因子结合蛋白。在非转基因同窝幼崽中，IGFBP4 mRNA 的表达在肝脏和肾脏中最高。

IGFBP4, insulin like growth factor binding protein 4 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IGFBP4 分子靶点信息

  • 分子名：IGFBP4, insulin like growth factor binding protein 4
  • 别称：
    • BP-4
    • HT29-IGFBP
    • IBP-4
    • IBP4
    • IGF-binding protein 4
    • IGFBP-4
    • insulin-like growth factor binding protein 4
    • insulin-like growth factor-binding protein 4
  • 基因序列：NCBI_Gene: 3487
  • 蛋白序列：UniProtKB: P22692

人 Human IGFBP4靶点分子功能（预测）

Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Predicted to be located in endoplasmic reticulum lumen and extracellular region. Predicted to be active in extracellular space.

小鼠 Mouse Igfbp4 分子靶点信息

小鼠 Mouse Igfbp4 靶点分子功能（预测）

Enables insulin-like growth factor binding activity. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; early embryo; female reproductive system; limb; and lung. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4).

大鼠 Rat Igfbp4 分子靶点信息

  • 分子名：Igfbp4, insulin-like growth factor binding protein 4
  • 别称：
    • IBP-4
    • IBP4
    • IGF-binding protein 4
    • IGF-BP4
    • IGFBP-4
    • insulin-like growth factor-binding protein 4
  • 基因序列：NCBI_Gene: 360622
  • 蛋白序列：UniProtKB: P21744

大鼠 Rat Igfbp4 靶点分子功能（预测）

Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in inflammatory response. Predicted to be active in extracellular space. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4).

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