IGFBP3 靶点信息

IGFBP3 分子靶点信息概述

  • 分子名：IGFBP3, insulin like growth factor binding protein 3
  • 基因家族：Insulin like growth factor binding proteins
  • 别名：IBP3; BP-53
  • 全称：growth hormone-dependent binding protein; acid stable subunit of the 140 K IGF complex; binding protein 53; binding protein 29; IGF-binding protein 3; insulin-like growth factor binding protein 3

IGFBP3 分子靶点综述

胰岛素样生长因子结合蛋白3(IGFBP-3)，在人类中由IGFBP3基因编码。IGFBP-3是六个IGF结合蛋白(IGFBP-1至6)中的一个，这些结合蛋白具有高度保守结构，并可高亲和力结合IGF-1和IGF-2。IGFBP-3是血液中IGF的主要转运蛋白。它与细胞表面蛋白相互作用，影响胞外或内化后的细胞信号，它也可进入细胞核，在这里，它结合核激素受体和其它配体。基于细胞生长实验、动物癌症模型和流行病学研究，IGFBP-3似乎可作为低外显率的肿瘤抑制基因。失调的IGFBP-3参与许多癌症。血清中IGFBP-3水平可用来筛选生长激素是否缺乏。在AIDS、不受控制的糖尿病、创伤和严重烧伤患者的血清中，IGFBP-3水平是下降的。

IGFBP3, insulin like growth factor binding protein 3 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IGFBP3 分子靶点信息

  • 分子名：IGFBP3, insulin like growth factor binding protein 3
  • 别称：
    • acid stable subunit of the 140 K IGF complex
    • binding protein 29
    • binding protein 53
    • BP-53
    • growth hormone-dependent binding protein
    • IBP-3
    • IBP3
    • IGF-binding protein 3
    • IGFBP-3
    • insulin-like growth factor binding protein 3
    • insulin-like growth factor-binding protein 3
  • 基因序列：NCBI_Gene: 3486
  • 蛋白序列：UniProtKB: P17936

人 Human IGFBP3靶点分子功能（预测）

Enables insulin-like growth factor I binding activity and protein tyrosine phosphatase activator activity. Involved in several processes, including negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; and positive regulation of myoblast differentiation. Acts upstream of or within negative regulation of cell population proliferation; negative regulation of protein phosphorylation; and protein phosphorylation. Located in extracellular space and nucleus. Part of insulin-like growth factor ternary complex. Implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Biomarker of several diseases, including Barrett's esophagus; Down syndrome; autoimmune disease (multiple); bone disease (multiple); and urinary system cancer (multiple).

小鼠 Mouse Igfbp3 分子靶点信息

小鼠 Mouse Igfbp3 靶点分子功能（预测）

Enables fibronectin binding activity and insulin-like growth factor binding activity. Acts upstream of or within several processes, including osteoblast differentiation; positive regulation of signal transduction; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early embryo; gonad; and limb. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).

大鼠 Rat Igfbp3 分子靶点信息

大鼠 Rat Igfbp3 靶点分子功能（预测）

Enables insulin-like growth factor II binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to estradiol stimulus; and response to peptide hormone. Located in extracellular space; heterochromatin; and platelet alpha granule. Part of insulin-like growth factor binary complex and insulin-like growth factor ternary complex. Used to study impotence. Biomarker of congenital diaphragmatic hernia; impotence; and obesity. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).

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