IGFBP2 靶点信息

IGFBP2 分子靶点信息概述

  • 分子名：IGFBP2, insulin like growth factor binding protein 2
  • 基因家族：Insulin like growth factor binding proteins
  • 曾用名：IBP2
  • 全称：insulin-like growth factor binding protein 2 (36kD); insulin-like growth factor binding protein 2, 36kDa; insulin-like growth factor binding protein 2

IGFBP2 分子靶点综述

胰岛素样生长因子结合蛋白 (IGFBP) 在修饰多种细胞类型的胰岛素样生长因子 (IGF) 的作 用方面发挥不可或缺的作用。该家族有六个结构相关但由不同基因编码的成员。IGFBP2 是循环中 第二个最丰富的 IGFBP，存在于许多脊椎动物的其他生物流体和组织中。在休克、空腹、低氧血 症或创伤后的情况下血清 IGFBP2 水平会升高，提示 IGFBP2 表达的复杂调节。在许多恶性肿瘤中 IGFBP2 呈现过表达，且与肿瘤的恶性程度相关，提示 IGFBP2 可能参与肿瘤发生。在发育过程中， IGFBP-2 在多个组织中表达。在中枢神经系统中其表达水平最高。在成人中枢神经系统和许多生 殖组织中也检测到其高表达水平.

IGFBP2, insulin like growth factor binding protein 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IGFBP2 分子靶点信息

  • 分子名：IGFBP2, insulin like growth factor binding protein 2
  • 别称：
    • IBP-2
    • IBP2
    • IGF-binding protein 2
    • IGF-BP53
    • IGFBP-2
    • insulin-like growth factor binding protein 2
    • insulin-like growth factor binding protein 2, 36kDa
    • insulin-like growth factor-binding protein 2
  • 基因序列：NCBI_Gene: 3485
  • 蛋白序列：UniProtKB: P18065

人 Human IGFBP2靶点分子功能（预测）

Enables insulin-like growth factor I binding activity. Involved in positive regulation of activated T cell proliferation. Located in extracellular space. Implicated in obesity. Biomarker of Alzheimer's disease; Kuhnt-Junius degeneration; and obesity.

小鼠 Mouse Igfbp2 分子靶点信息

小鼠 Mouse Igfbp2 靶点分子功能（预测）

Enables insulin-like growth factor binding activity. Predicted to be involved in positive regulation of activated T cell proliferation and regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within regulation of growth. Located in extracellular space. Is expressed in several structures, including brain; early embryo; limb; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).

大鼠 Rat Igfbp2 分子靶点信息

  • 分子名：Igfbp2, insulin-like growth factor binding protein 2
  • 别称：
    • BRL-BP
    • IBP-2
    • IGF-binding protein 2
    • IGFBP-2
    • ILGFBPA
    • insulin-like growth factor-binding protein 2
  • 基因序列：NCBI_Gene: 25662
  • 蛋白序列：UniProtKB: P12843

大鼠 Rat Igfbp2 靶点分子功能（预测）

Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including response to estradiol; response to estrogen; and response to retinoic acid. Located in apical plasma membrane; cytoplasmic vesicle; and extracellular space. Biomarker of hypertension and hypothyroidism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).

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