IGF1R 靶点信息

IGF1R 分子靶点信息概述

  • 分子名：IGF1R, insulin like growth factor 1 receptor
  • 基因家族：Receptor tyrosine kinases; CD molecules; Fibronectin type III domain containing; MicroRNA protein coding host genes
  • 别名：JTK13; CD221; IGFIR; MGC18216; IGFR
  • 全称：insulin-like growth factor 1 receptor

IGF1R 分子靶点综述

胰岛素样生长因子1受体(IGF-1R)位于人类细胞表面，是受激素胰岛素样生长因子1(IGF-1)和另一相关激素胰岛素样生长因子2(IGF-2)激活的跨膜受体，属于酪氨酸激酶受体的一大类。IGF-1R介导IGF-1的功能，后者是一个在分子结构上类似于胰岛素的多肽蛋白激素，在生长发育和成人的合成代谢中有重要作用，可引起骨骼肌或其它靶组织的过度增殖。缺失IGF-1R的小鼠在发育后期会死亡，表现为体重急剧下降，证明该受体对生长具有强烈的促进作用。研究表明IGF-1R与一些癌症，包括乳腺癌、前列腺癌和肺癌有关。

IGF1R, insulin like growth factor 1 receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IGF1R 分子靶点信息

  • 分子名：IGF1R, insulin like growth factor 1 receptor
  • 别称：
    • CD221
    • IGF-I receptor
    • IGFIR
    • IGFR
    • insulin-like growth factor 1 receptor
    • insulin-like growth factor I receptor
    • JTK13
    • MGC142170
    • MGC142172
    • MGC18216
    • soluble IGF1R variant 1
    • soluble IGF1R variant 2
  • 基因序列：NCBI_Gene: 3480
  • 蛋白序列：UniProtKB: P08069

人 Human IGF1R靶点分子功能（预测）

Enables several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; insulin-like growth factor receptor signaling pathway; and regulation of MAPK cascade. Acts upstream of or within peptidyl-tyrosine autophosphorylation. Located in intracellular membrane-bounded organelle and membrane. Part of alphav-beta3 integrin-IGF-1-IGF1R complex; protein kinase complex; and receptor complex. Implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Biomarker of several diseases, including Kuhnt-Junius degeneration; autoimmune disease (multiple); endocrine gland cancer (multiple); neurodegenerative disease (multiple); and prostate disease (multiple).

小鼠 Mouse Igf1r 分子靶点信息

小鼠 Mouse Igf1r 靶点分子功能（预测）

Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development; positive regulation of cold-induced thermogenesis; and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).

大鼠 Rat Igf1r 分子靶点信息

大鼠 Rat Igf1r 靶点分子功能（预测）

Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).

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