文章目录[隐藏]
IGF1 分子靶点信息概述
- 分子名:IGF1, insulin like growth factor 1
- 基因家族:Neuropeptides
- 别名:IGF1A; IGFI; IGF-I; IGF
- 全称:somatomedin C; insulin-like growth factor 1 (somatomedin C)
IGF1 分子靶点综述
胰岛素样生长因子1(IGF-1),也称为生长调节素C,是一个在分子结构上类似于胰岛素的激素。IGF-1主要由肝脏产生,作为内分泌激素。同样地,靶组织亦能旁分泌/自分泌产生IGF-1。IGF-1是AKT信号转导途径中的一种有效天然激活剂、细胞生长和增殖的刺激子、细胞程序性死亡的有效抑制子。IGF-1最少可结合两种细胞表面受体:IGF-1受体(IGF1R)和胰岛素受体。IGF-1的产生受生长激素刺激,受营养不良、生长激素不敏感、缺少生长激素受体或者生长激素受体(SHP2和STAT5B)下游信号通路发生故障等方面所抑制。IGF-1在儿童生长过程中起重要作用,继而在成人合成代谢中有影响,且与老年化、神经病变、癌症以及中风相关。
IGF1, insulin like growth factor 1 分子靶点种属信息
人 Human IGF1 分子靶点信息
- 分子名:IGF1, insulin like growth factor 1
- 别称:
- IGF
- IGF-I
- IGF-IA
- IGF-IB
- IGF1A
- IGFI
- insulin-like growth factor 1
- insulin-like growth factor 1 (somatomedin C)
- insulin-like growth factor I
- insulin-like growth factor IA
- insulin-like growth factor IB
- mechano growth factor
- MGF
- somatomedin-C
- 基因序列:NCBI_Gene: 3479
- 蛋白序列:UniProtKB: P05019
人 Human IGF1靶点分子功能(预测)
Enables signaling receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Acts upstream of or within cell activation. Located in extracellular space. Part of alphav-beta3 integrin-IGF-1-IGF1R complex and insulin-like growth factor ternary complex. Implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Biomarker of several diseases, including Henoch-Schoenlein purpura; artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); and eye disease (multiple).
小鼠 Mouse Igf1 分子靶点信息
- 分子名:Igf1, insulin-like growth factor 1
- 别称:
- C730016P09Rik
- Igf-1
- Igf-I
- RIKEN cDNA C730016P09 gene
- 基因序列:NCBI_Gene: 16000
- 蛋白序列:
小鼠 Mouse Igf1 靶点分子功能(预测)
Enables insulin receptor binding activity and insulin-like growth factor receptor binding activity. Involved in negative regulation of gene expression; negative regulation of release of cytochrome c from mitochondria; and positive regulation of myelination. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in exocytic vesicle and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including acne; artery disease (multiple); diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1).
大鼠 Rat Igf1 分子靶点信息
- 分子名:Igf1, insulin-like growth factor 1
- 别称:
- IGF
- IGF-I
- insulin-like growth factor I
- somatomedin
- 基因序列:NCBI_Gene: 24482
- 蛋白序列:
大鼠 Rat Igf1 靶点分子功能(预测)
Enables protein serine/threonine kinase activator activity; signaling receptor binding activity; and steroid binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of cell death; and positive regulation of cell differentiation. Located in several cellular components, including interstitial matrix; neuronal cell body; and platelet alpha granule. Used to study brain ischemia; diabetic neuropathy; and hypertension. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); congenital diaphragmatic hernia; folic acid deficiency anemia; and hypothyroidism (multiple). Human ortholog(s) of this gene implicated in several diseases, including acne; brain ischemia; diabetes mellitus (multiple); myopia; and neurodegenerative disease (multiple). Orthologous to human IGF1 (insulin like growth factor 1).
IGF1 分子产品列表
-
- EK9131
- ELISA试剂盒
Mouse/Rat IGF-1 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
-
- EK9131S
- ELISA标准品
Mouse/Rat IGF-1 Standard (小鼠/大鼠IGF-1 标准品)
- ¥180.00
-
- EK1131
- ELISA试剂盒
Human IGF-1 ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00
-
- EK1131S
- ELISA标准品
Human IGF-1 Standard (人胰岛素样生长因子1 标准品)
- ¥280.00