IFNL1 靶点信息

IFNL1 分子靶点信息概述

  • 分子名：IFNL1, interferon lambda 1
  • 基因家族：Interferons
  • 别名：IL-29
  • 曾用名：IL29
  • 全称：interleukin 29; interleukin 29 (interferon, lambda 1)

IFNL1 分子靶点综述

白细胞介素29(IL-29)，又名干扰素λ1(IFN-λ1)，是螺旋细胞因子家族中的一员，是一种III型干扰素。它的氨基酸序列和另一个III型干扰素-IL-28高度相似。IL-29基因是在人类19号染色体上发现的，但是却不存在于小鼠基因组中。IL-29在宿主防御微生物中起重要作用，其基因在病毒感染细胞中高度上调。IL-29具有显著的抗病毒活性和免疫调节特性，可通过诱导类似于IFN-α/β激活的细胞抗病毒应答来抑制病毒复制。然而，IL-29是结合到一个独特的受体上，因此在自然感染过程中，该细胞因子可能与IFN-α/β或者IFN-γ协同作用来抑制病毒复制，也可能与其它细胞因子一起联合治疗慢性病毒感染如丙型肝炎(HCV)。IL-29的抗病毒活性包括I类MHC在细胞表面表达的上调和PKR表达的上调。配体/受体复合物似乎通过Jak-STAT途径传导信号。

IFNL1, interferon lambda 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IFNL1 分子靶点信息

  • 分子名：IFNL1, interferon lambda 1
  • 别称：
    • cytokine Zcyto21
    • IFN-lambda-1
    • IL-29
    • IL29
    • interferon lambda-1
    • interferon-lambda-1
    • interferon, lambda 1
    • interleukin 29 (interferon, lambda 1)
    • interleukin-29
  • 基因序列：NCBI_Gene: 282618
  • 蛋白序列：UniProtKB: Q8IU54

人 Human IFNL1靶点分子功能（预测）

Enables interleukin-28 receptor binding activity. Involved in several processes, including negative regulation of immune response; positive regulation of macromolecule metabolic process; and regulation of gene expression. Located in extracellular region. Part of interleukin-28 receptor complex. Implicated in COVID-19; dengue hemorrhagic fever; hepatitis C; and hepatocellular carcinoma. Biomarker of asthma; dengue disease; subacute sclerosing panencephalitis; and tropical spastic paraparesis.

小鼠 Mouse Ifnl2 分子靶点信息

小鼠 Mouse Ifnl2 靶点分子功能（预测）

Predicted to enable interleukin-28 receptor binding activity. Involved in defense response to virus and mucosal immune response. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to several human genes including IFNL2 (interferon lambda 2) and IFNL3 (interferon lambda 3).

大鼠 Rat Ifnl1 分子靶点信息

  • 分子名：Ifnl1, interferon, lambda 1
  • 别称：
    • If1ia2
    • interferon 1ia2
    • interferon lambda-2-like
    • interleukin-28A-like
    • LOC100911249
  • 基因序列：NCBI_Gene: 100911249
  • 蛋白序列：UniProtKB: A0A0G2JWM7

大鼠 Rat Ifnl1 靶点分子功能（预测）

Predicted to enable interleukin-28 receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of immune response; and regulation of gene expression. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to human IFNL1 (interferon lambda 1); IFNL2 (interferon lambda 2); and IFNL3 (interferon lambda 3).

IFNL1 分子产品列表

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