IFNB1 靶点信息

IFNB1 分子靶点信息概述

  • 分子名：IFNB1, interferon beta 1
  • 基因家族：Interferons
  • 别名：IFB; IFF
  • 曾用名：IFNB
  • 全称：interferon, beta 1, fibroblast

IFNB1 分子靶点综述

干扰素(IFNs)是宿主细胞在响应病原体(如病毒、细菌、寄生虫或者肿瘤细胞)时合成和释放的一组信号蛋白。在通常情况下，病毒感染的细胞会释放干扰素，使周围的细胞提高其抗病毒防御能力。基于受体类型，人类干扰素可分为3大类型：I型干扰素，包括IFN-α、IFN-β、IFN-ε、IFN-κ和IFN-ω，II型干扰素(在人类中称为IFN-γ)和III型干扰素。IFN-β通过信号通路STAT1和STAT2上调和下调多种基因，其中，大部分基因参与抗病毒免疫反应。IFN-β在诱导广泛的非特异性抗病毒感染中起重要作用，它还影响细胞增殖并调节免疫应答。

IFNB1, interferon beta 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human IFNB1 分子靶点信息

  • 分子名：IFNB1, interferon beta 1
  • 别称：
    • fibroblast interferon
    • IFB
    • IFF
    • IFN-beta
    • IFNB
    • interferon beta
    • interferon-beta
    • interferon, beta 1
    • interferon, beta 1, fibroblast
    • MGC96956
  • 基因序列：NCBI_Gene: 3456
  • 蛋白序列：UniProtKB: P01574

人 Human IFNB1靶点分子功能（预测）

Enables chloramphenicol O-acetyltransferase activity and cytokine activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of T-helper 2 cell cytokine production; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within response to exogenous dsRNA. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in COVID-19.

小鼠 Mouse Ifnb1 分子靶点信息

小鼠 Mouse Ifnb1 靶点分子功能（预测）

Enables cytokine activity and type I interferon receptor binding activity. Involved in B cell proliferation; cellular response to virus; and type I interferon signaling pathway. Acts upstream of or within several processes, including cellular response to organic cyclic compound; defense response to other organism; and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1).

大鼠 Rat Ifnb1 分子靶点信息

  • 分子名：Ifnb1, interferon beta 1
  • 别称：
    • If1da1
    • IFN-beta
    • Ifnb
    • interferon 1da1
    • interferon beta
    • Interferon beta 1 fibroblast
    • interferon beta 1, fibroblast
    • interferon, beta 1
    • Interferon, beta 1, fibroblast
  • 基因序列：NCBI_Gene: 24481
  • 蛋白序列：

大鼠 Rat Ifnb1 靶点分子功能（预测）

Predicted to enable chloramphenicol O-acetyltransferase activity; cytokine activity; and type I interferon receptor binding activity. Involved in macrophage activation involved in immune response. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFNB1 (interferon beta 1).

IFNB1 分子产品列表

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