IFNA1 靶点信息

IFNA1 分子靶点信息概述

  • 分子名：IFNA1, interferon alpha 1
  • 基因家族：Interferons
  • 别名：IFNA@; IFL; IFN; IFN-ALPHA; IFNA13; IFN-alphaD
  • 全称：IFN-alpha 1b; interferon alpha 1b

IFNA1 分子靶点综述

干扰素(IFNs)是宿主细胞在响应病原体(如病毒、细菌、寄生虫或者肿瘤细胞)时合成和释放的一组信号蛋白。在通常情况下，病毒感染的细胞会释放干扰素，使周围的细胞提高其抗病毒防御能力。基于受体类型，人类干扰素可分为3大类型：I型干扰素，包括IFN-α、IFN-β、IFN-ε、IFN-κ和IFN-ω，II型干扰素(在人类中称为IFN-γ)和III型干扰素。IFN-α蛋白由白细胞产生，主要参与响应病毒感染的先天性免疫。研究显示加强肿瘤浸润巨噬细胞中IFN-α的表达可引起更有效的树突状细胞活化和免疫效应细胞毒作用。IFN-α作为致热因子，可通过改变下丘脑中热敏神经元的活性来导致发热。运用类似机理，IFN-α可用来减轻疼痛，与μ-阿片受体相互作用来作为止痛剂。

IFNA1, interferon alpha 1 分子靶点种属信息

人 Human小鼠 Mouse

人 Human IFNA1 分子靶点信息

  • 分子名：IFNA1, interferon alpha 1
  • 别称：
    • IFL
    • IFN
    • IFN-ALPHA
    • IFN-alpha 1b
    • IFN-alpha-1/13
    • IFN-alphaD
    • IFNA@
    • IFNA13
    • interferon alpha 1b
    • interferon alpha-1/13
    • interferon alpha-D
    • interferon-alpha1
    • interferon, alpha 1
    • leIF D
    • MGC138207
    • MGC138505
    • MGC138507
  • 基因序列：NCBI_Gene: 3439
  • 蛋白序列：UniProtKB: P01562

人 Human IFNA1靶点分子功能（预测）

Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in Crimean-Congo hemorrhagic fever and hepatocellular carcinoma. Biomarker of melioidosis.

小鼠 Mouse Ifna1 分子靶点信息

小鼠 Mouse Ifna1 靶点分子功能（预测）

Enables cytokine activity. Involved in regulation of defense response to virus by host and type I interferon signaling pathway. Acts upstream of or within defense response to other organism and lymphocyte activation involved in immune response. Located in extracellular space. Is expressed in embryo. Human ortholog(s) of this gene implicated in Crimean-Congo hemorrhagic fever; common cold; hepatitis B; liver disease (multiple); and sarcoidosis. Orthologous to several human genes including IFNA10 (interferon alpha 10); IFNA14 (interferon alpha 14); and IFNA16 (interferon alpha 16).

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