HSP90B1 靶点信息

HSP90B1 分子靶点信息概述

  • 分子名：HSP90B1, heat shock protein 90 beta family member 1
  • 基因家族：Heat shock 90kDa proteins; MicroRNA protein coding host genes
  • 别名：GP96; GRP94
  • 曾用名：TRA1
  • 全称：tumor rejection antigen (gp96) 1; heat shock protein 90kDa beta (Grp94), member 1; endoplasmin

HSP90B1 分子靶点综述

热休克蛋白 90 kDa β1（Heat Shock Protein 90kDa Beta 1，HSP90b1），GeneID:7184；HGNC:12028；UniProtID: P14625。
按照蛋白的大小，热休克蛋白共分为五类，分别为 HSP110、HSP90、HSP70、HSP60 以及小分子热休克蛋白 small Heat Shock Proteins (sHSPs)。HSP90 是人体中含量最丰富的蛋白之一，细胞内每百个蛋白中就有 1-2 个由 HSP90 构成。它也是细胞中必不可缺的分子伴侣蛋白之一，表达于所有的真核细胞，并且其在肿瘤细胞中的表达比正常细胞要高出 2~10 倍。HSP90 主要分为 HSP90α、HSP90β、Grp94 和 Trap-1 四种亚型。HSP90β1 由 315 个 AA 构成。该基因编码三磷酸腺苷 ( adenosine triphosphate，ATP ) 代谢分子伴侣家族成员，具有稳定和折叠其他蛋白质的作用。编码的蛋白定位于黑素小体和内质网。该蛋白的表达与多种病理状态相关，包括肿瘤的形成。有一个 microRNA 基因位于该基因的 5 '外显子内。该基因在第 1 和第 15 染色体上存在假基因。

HSP90B1, heat shock protein 90 beta family member 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human HSP90B1 分子靶点信息

  • 分子名：HSP90B1, heat shock protein 90 beta family member 1
  • 别称：
    • 94 kDa glucose-regulated protein
    • ECGP
    • endoplasmin
    • endothelial cell (HBMEC) glycoprotein
    • epididymis luminal protein 35
    • epididymis secretory sperm binding protein Li 125m
    • glucose regulated protein, 94 kDa
    • GP96
    • gp96 homolog
    • GRP-94
    • GRP94
    • heat shock protein 90 kDa beta member 1
    • heat shock protein 90kDa beta (Grp94), member 1
    • heat shock protein 90kDa beta family member 1
    • HEL-S-125m
    • HEL35
    • stress-inducible tumor rejection antigen gp96
    • TRA1
    • tumor rejection antigen (gp96) 1
    • tumor rejection antigen 1
    • Tumor rejection antigen-1 (gp96)
  • 基因序列：NCBI_Gene: 7184
  • 蛋白序列：UniProtKB: P14625

人 Human HSP90B1 靶点分子功能（预测）

Enables RNA binding activity; low-density lipoprotein particle receptor binding activity; and protein phosphatase binding activity. Involved in negative regulation of apoptotic process; response to hypoxia; and retrograde protein transport, ER to cytosol. Acts upstream of or within actin rod assembly and cellular response to ATP. Located in several cellular components, including endoplasmic reticulum; midbody; and perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of lung adenocarcinoma.

小鼠 Mouse Hsp90b1 分子靶点信息

小鼠 Mouse Hsp90b1 靶点分子功能（预测）

Predicted to enable several functions, including low-density lipoprotein particle receptor binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in ERAD pathway; insulin processing; and protein folding. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Located in endoplasmic reticulum and sperm plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including central nervous system; heart; metanephros; pancreas; and respiratory system. Used to study male infertility due to globozoospermia. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1).

大鼠 Rat Hsp90b1 分子靶点信息

  • 分子名：Hsp90b1, heat shock protein 90 beta family member 1
  • 别称：
    • 94 kDa glucose-regulated protein
    • endoplasmin
    • GRP-94
    • GRP94
    • heat shock protein 90 kDa beta member 1
    • heat shock protein 90, beta, member 1
    • heat shock protein 90kDa beta (Grp94), member 1
    • LOC362862
    • Tra1
    • tumor rejection antigen gp96
  • 基因序列：NCBI_Gene: 362862
  • 蛋白序列：

大鼠 Rat Hsp90b1 靶点分子功能（预测）

Predicted to enable several functions, including low-density lipoprotein particle receptor binding activity; protein phosphatase binding activity; and unfolded protein binding activity. Involved in cellular response to manganese ion. Located in smooth endoplasmic reticulum. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1).

HSP90B1 分子产品列表

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