HAVCR2 靶点信息

HAVCR2 分子靶点信息概述

  • 分子名：HAVCR2, hepatitis A virus cellular receptor 2
  • 基因家族：V-set domain containing
  • 别名：Tim-3; TIM3; FLJ14428; TIMD3; CD366
  • 全称：T-cell immunoglobulin mucin family member 3

HAVCR2 分子靶点综述

CD366，又名TIM-3，是一种I型跨膜糖蛋白，属于免疫球蛋白超家族内TIM家族。CD366在Th1、Th17、Treg、NK、NK-T、树突细胞、单核细胞、肥大细胞和巨噬细胞上表达，但不表达在B细胞和Th2细胞。CD366调节巨噬细胞活化并且是Th1细胞功能的负调节剂。

HAVCR2, hepatitis A virus cellular receptor 2 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human HAVCR2 分子靶点信息

  • 分子名：HAVCR2, hepatitis A virus cellular receptor 2
  • 别称：
    • CD366
    • FLJ14428
    • HAVcr-2
    • kidney injury molecule-3
    • KIM-3
    • SPTCL
    • T cell immunoglobulin mucin 3
    • T cell immunoglobulin mucin-3
    • T-cell immunoglobulin and mucin domain-containing protein 3
    • T-cell immunoglobulin mucin family member 3
    • T-cell immunoglobulin mucin receptor 3
    • T-cell membrane protein 3
    • Tim-3
    • TIM3
    • TIMD-3
    • TIMD3
  • 基因序列：NCBI_Gene: 84868
  • 蛋白序列：UniProtKB: Q8TDQ0

人 Human HAVCR2靶点分子功能（预测）

Predicted to enable metal ion binding activity. Involved in several processes, including natural killer cell tolerance induction; negative regulation of leukocyte activation; and regulation of cytokine production. Located in cell surface. Implicated in hepatocellular carcinoma and renal cell carcinoma. Biomarker of cystic fibrosis and pulmonary tuberculosis.

小鼠 Mouse Havcr2 分子靶点信息

小鼠 Mouse Havcr2 靶点分子功能（预测）

Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and toll-like receptor signaling pathway. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including dorsal aorta; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).

大鼠 Rat Havcr2 分子靶点信息

  • 分子名：Havcr2, hepatitis A virus cellular receptor 2
  • 别称：
    • HAVcr-2
    • hepatitis A virus cellular receptor 2 homolog
    • LOC363578
    • T cell immunoglobulin mucin-3
    • T-cell immunoglobulin and mucin domain-containing protein 3
    • T-cell immunoglobulin mucin receptor 3
    • T-cell membrane protein 3
    • TIM-3
    • tim3
    • TIMD-3
  • 基因序列：NCBI_Gene: 363578
  • 蛋白序列：UniProtKB: P0C0K5

大鼠 Rat Havcr2 靶点分子功能（预测）

Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and toll-like receptor signaling pathway. Located in cell surface. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).

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