HAVCR1 靶点信息

HAVCR1 分子靶点信息概述

  • 分子名：HAVCR1, hepatitis A virus cellular receptor 1
  • 基因家族：CD molecules; V-set domain containing
  • 别名：HAVCR-1; TIM-1; TIM1; HAVCR; TIMD1; CD365; KIM1
  • 全称：T-cell immunoglobulin mucin family member 1; kidney injury molecule 1

HAVCR1 分子靶点综述

T细胞免疫球蛋白域粘蛋白域蛋白-1 (TIM-1) 也称为肾损伤因子-1 (KIM-1) 和甲型肝炎病毒细胞受体1 (HAVcr1)，是TIM基因家族的成员，对调控免疫细胞活性尤其是是对病毒感染的宿主免疫应答发挥关键作用。TIM-1优先表达于Th2细胞，是T细胞活化的刺激分子。TIM-1也参与了过敏反应、哮喘和移植耐受。在人类中，TIM-1可作为多种病毒进入细胞的受体，包括甲型肝炎病毒、登革病毒和埃博拉病毒。

HAVCR1, hepatitis A virus cellular receptor 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human HAVCR1 分子靶点信息

  • 分子名：HAVCR1, hepatitis A virus cellular receptor 1
  • 别称：
    • CD365
    • HAVCR
    • HAVCR-1
    • kidney injury molecule 1
    • KIM-1
    • KIM1
    • T cell immunoglobin domain and mucin domain protein 1
    • T-cell immunoglobulin mucin family member 1
    • T-cell immunoglobulin mucin receptor 1
    • T-cell membrane protein 1
    • TIM
    • TIM-1
    • TIM1
    • TIMD-1
    • TIMD1
  • 基因序列：NCBI_Gene: 26762
  • 蛋白序列：UniProtKB: Q96D42

人 Human HAVCR1靶点分子功能（预测）

Enables virus receptor activity. Predicted to be involved in phagocytosis, engulfment and positive regulation of mast cell activation. Predicted to act upstream of or within response to lipopolysaccharide and response to wounding. Part of motile cilium. Implicated in atopic dermatitis. Biomarker of several diseases, including hydronephrosis; hyperuricemia; kidney disease (multiple); relapsing-remitting multiple sclerosis; and vesicoureteral reflux.

小鼠 Mouse Havcr1 分子靶点信息

小鼠 Mouse Havcr1 靶点分子功能（预测）

Enables phosphatidylserine binding activity. Acts upstream of or within positive regulation of mast cell activation; response to lipopolysaccharide; and response to wounding. Located in brush border and cell surface. Is expressed in brain; dorsal aorta; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).

大鼠 Rat Havcr1 分子靶点信息

  • 分子名：Havcr1, hepatitis A virus cellular receptor 1
  • 别称：
    • HAVcr-1
    • hepatitis A virus cellular receptor 1 homolog
    • kidney injury molecule 1
    • KIM-1
    • Kim1
    • t cell immunoglobulin and mucin domain-containing protein 1
    • TIMD-1
  • 基因序列：NCBI_Gene: 286934
  • 蛋白序列：

大鼠 Rat Havcr1 靶点分子功能（预测）

Predicted to enable phosphatidylserine binding activity and virus receptor activity. Involved in several processes, including phagocytosis, engulfment; response to mycotoxin; and response to testosterone. Located in several cellular components, including apical plasma membrane; cell surface; and phagocytic vesicle. Biomarker of colitis; hypertension; kidney failure (multiple); and proteinuria (multiple). Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1).

HAVCR1 分子产品列表

HAVCR1 分子靶点最新资讯

你知道体液免疫的驱动精灵吗？