GZMB 靶点信息

GZMB 分子靶点信息概述

  • 分子名：GZMB, granzyme B
  • 基因家族：Granule associated serine proteases of immune defence
  • 别名：CCPI; CGL-1; CSP-B; CGL1; CTSGL1; HLP; SECT
  • 曾用名：CTLA1; CSPB
  • 全称：fragmentin 2; cytotoxic serine protease B; cathepsin G-like 1; T-cell serine protease 1-3E; granzyme 2; cytotoxic T-lymphocyte-associated serine esterase 1; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

GZMB 分子靶点综述

颗粒酶B(GranzymeB)是一种丝氨酸蛋白酶，最常见于细胞毒性淋巴细胞(CTLs)和自然杀伤细胞(NK细胞)颗粒中。由这些细胞分泌的GranzymeB和穿孔蛋白一起作用介导靶细胞的凋亡。最近，人们发现许多非细胞毒性细胞从嗜碱性粒细胞、肥大细胞到平滑肌细胞也可产生GranzymeB。GranzymeB通过刺激细胞因子的释放参与诱导炎症，同样也参与细胞外基质重塑。升高的GranzymeB水平与许多自身免疫性疾病、一些皮肤病和1型糖尿病有关。

GZMB, granzyme B 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human GZMB 分子靶点信息

  • 分子名：GZMB, granzyme B
  • 别称：
    • C11
    • cathepsin G-like 1
    • CCPI
    • CGL-1
    • CGL1
    • CSP-B
    • CSPB
    • CTLA-1
    • CTLA1
    • CTSGL1
    • cytotoxic serine protease B
    • cytotoxic T-lymphocyte proteinase 2
    • cytotoxic T-lymphocyte-associated serine esterase 1
    • fragmentin 2
    • fragmentin-2
    • granzyme 2
    • granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
    • granzyme-2
    • HLP
    • human lymphocyte protein
    • lymphocyte protease
    • SECT
    • T-cell serine protease 1-3E
  • 基因序列：NCBI_Gene: 3002
  • 蛋白序列：UniProtKB: P10144

人 Human GZMB靶点分子功能（预测）

Enables serine-type endopeptidase activity. Involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Located in cytolytic granule. Biomarker of COVID-19; bronchiolitis obliterans; and chronic obstructive pulmonary disease.

小鼠 Mouse Gzme 分子靶点信息

  • 分子名：Gzme, granzyme E
  • 别称：
    • CCP3
    • Ctla-6
    • Ctla6
    • cytotoxic T lymphocyte-associated protein 6
    • MCSP-2
  • 基因序列：NCBI_Gene: 14942
  • 蛋白序列：

小鼠 Mouse Gzme 靶点分子功能（预测）

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptosis. Predicted to act upstream of or within cytolysis. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in extraembryonic component; placenta; spongiotrophoblast; and trophoblast giant cell. Orthologous to human GZMB (granzyme B).

大鼠 Rat Gzmb 分子靶点信息

  • 分子名：Gzmb, granzyme B
  • 别称：
    • fragmentin
    • GLP I
    • GLP III
    • GLP-1
    • granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
    • granzyme-like protein 1
    • granzyme-like protein I
    • LOW QUALITY PROTEIN: granzyme-like protein 1
    • MGC156565
    • natural killer cell protease 1
    • RNKP-1
  • 基因序列：NCBI_Gene: 171528
  • 蛋白序列：

大鼠 Rat Gzmb 靶点分子功能（预测）

Enables serine-type endopeptidase activity. Involved in positive regulation of necroptotic process. Located in early endosome. Orthologous to human GZMB (granzyme B).

GZMB 分子产品列表

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