GRN 靶点信息

GRN 分子靶点信息概述

  • 分子名：GRN, granulin precursor
  • 别名：PCDGF; PGRN; CLN11
  • 全称：progranulin

GRN 分子靶点综述

颗粒体蛋白(GRN)在人类中由GRN基因编码。它的前体蛋白—颗粒蛋白前体，又名畸胎瘤细胞源性生长因子。信号肽被剪切后可产生成熟的GRN，进一步剪切可产生许多分子量为6kDa的活性多肽。肽和完整的GRN都可调节细胞生长。然而，GRN蛋白家族的不同成员可能对细胞生长产生抑制和/或促进作用。GRN家族成员对正常发育、伤口愈合和肿瘤发生有重要作用。GRN可能有细胞因子样活性，可在炎症、创伤修复和组织重塑中发挥作用。人肝吸虫可分泌类似GRN的生长激素，从而导致胆管癌的发展。GRN基因突变可通过高外显率的常染色体显性遗传，产生最高达25%的额颞叶变性。

GRN, granulin precursor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human GRN 分子靶点信息

  • 分子名：GRN, granulin precursor
  • 别称：
    • acrogranin
    • CLN11
    • epithelin
    • GEP
    • glycoprotein 88
    • glycoprotein of 88 Kda
    • GP88
    • granulin
    • granulin-epithelin
    • granulins
    • PC cell-derived growth factor
    • PCDGF
    • PEPI
    • PGRN
    • proepithelin
    • progranulin
  • 基因序列：NCBI_Gene: 2896
  • 蛋白序列：UniProtKB: P28799

人 Human GRN靶点分子功能（预测）

Enables chaperone binding activity. Involved in several processes, including lysosomal lumen acidification; negative regulation of respiratory burst involved in inflammatory response; and positive regulation of lysosome organization. Located in several cellular components, including Golgi apparatus; late endosome; and lysosomal membrane. Implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Biomarker of several diseases, including Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; atherosclerosis; autistic disorder; multiple sclerosis (multiple); and neurodegenerative disease (multiple).

小鼠 Mouse Grn 分子靶点信息

小鼠 Mouse Grn 靶点分子功能（预测）

Predicted to enable chaperone binding activity. Involved in several processes, including astrocyte activation involved in immune response; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and lysosomal protein catabolic process. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is expressed in several structures, including early conceptus; gonad; integument; nervous system; and placenta. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).

大鼠 Rat Grn 分子靶点信息

大鼠 Rat Grn 靶点分子功能（预测）

Predicted to enable chaperone binding activity. Involved in several processes, including chondrocyte proliferation; positive regulation of dendritic spine development; and response to estradiol. Predicted to be located in several cellular components, including late endosome; lysosomal membrane; and trans-Golgi network. Predicted to be active in extracellular region. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).

GRN 分子产品列表

GRN 分子靶点最新资讯