GDNF 靶点信息

GDNF 分子靶点信息概述

  • 分子名：GDNF, glial cell derived neurotrophic factor
  • 基因家族：GDNF family ligands
  • 别名：ATF1; ATF2; HFB1-GDNF
  • 全称：astrocyte-derived trophic factor; glial cell line derived neurotrophic factor; glial derived neurotrophic factor

GDNF 分子靶点综述

胶质细胞源性神经营养因子(GDNF)是一种神经营养因子，在中枢神经系统和外周神经系统发育的不同阶段均能促进不同神经元亚群的存活。功能性人GDNF配体是一个二硫键连接的同源二聚体，由两个15kDa的多肽链组成。GDNF由支持细胞、1型星形胶质细胞、雪旺细胞、神经元、松果体细胞和骨骼肌细胞产生，它是一种能促进运动神经元、中脑多巴胺能神经元、浦肯野细胞和交感神经元存活的分泌性蛋白。GDNF对脊髓运动神经元的存活效率比神经营养蛋白高100倍。在帕金森病小鼠模型中发现，GDNF可以改善诸如运动迟缓、僵硬和姿势不稳定等状况。

GDNF, glial cell derived neurotrophic factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human GDNF 分子靶点信息

  • 分子名：GDNF, glial cell derived neurotrophic factor
  • 别称：
    • astrocyte-derived trophic factor
    • ATF
    • ATF1
    • ATF2
    • glial cell line derived neurotrophic factor
    • glial cell line-derived neurotrophic factor
    • HFB1-GDNF
    • hGDNF
    • HSCR3
  • 基因序列：NCBI_Gene: 2668
  • 蛋白序列：UniProtKB: P39905

人 Human GDNF靶点分子功能（预测）

Enables protein homodimerization activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of morphogenesis of an epithelium; and regulation of RNA metabolic process. Acts upstream of or within several processes, including neural crest cell migration; neuron projection development; and positive regulation of cell population proliferation. Located in Golgi apparatus and extracellular region. Implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Biomarker of acoustic neuroma; autoimmune disease (multiple); neurodegenerative disease (multiple); pancreatic cancer; and vasculitis (multiple).

小鼠 Mouse Gdnf 分子靶点信息

  • 分子名：Gdnf, glial cell line derived neurotrophic factor
  • 别称：
    • AI385739
    • expressed sequence AI385739
    • glial cell line-derived neurotrophic factor
  • 基因序列：NCBI_Gene: 14573
  • 蛋白序列：

小鼠 Mouse Gdnf 靶点分子功能（预测）

Predicted to enable protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including nervous system development; positive regulation of morphogenesis of an epithelium; and ureteric bud formation. Acts upstream of or within several processes, including negative regulation of neuron apoptotic process; nephron epithelium morphogenesis; and organ induction. Predicted to be located in Golgi apparatus and extracellular region. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and integumental system. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor).

大鼠 Rat Gdnf 分子靶点信息

大鼠 Rat Gdnf 靶点分子功能（预测）

Enables protein homodimerization activity and signaling receptor binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and regulation of morphogenesis of an epithelium. Located in extracellular space. Part of receptor complex. Used to study Parkinsonism and middle cerebral artery infarction. Biomarker of Parkinsonism and sciatic neuropathy. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor).

GDNF 分子产品列表

GDNF 分子靶点最新资讯

文献速递丨联科生物产品3月助力发表SCI论文145篇，最高影响因子达38.104