GCG 靶点信息

GCG 分子靶点信息概述

  • 分子名：GCG, glucagon
  • 基因家族：Receptor ligands
  • 别名：GLP1; GLP2; GRPP; GLP-1

GCG 分子靶点综述

胰高血糖素是由胰腺α细胞产生的一种肽类激素，由29个氨基酸组成，分子量为3485 Da，在葡萄糖代谢和稳态中起着至关重要的作用。胰高血糖素的作用是提高血液中葡萄糖的浓度，它也被用来作为药物治疗一些健康状况。它与降低葡萄糖的胰岛素作用相反。当血液中葡萄糖浓度过低时，胰腺释放胰高血糖素。胰高血糖素使肝脏中储存的糖原转化为葡萄糖，而后释放到血液中。另一方面，高血糖水平刺激胰岛素释放。胰高血糖素促使胰岛素依赖型组织吸收和消耗葡萄糖，因此，胰高血糖素和胰岛素是维持血糖水平稳定的反馈系统一部分。异常升高的胰高血糖素可能是由胰腺肿瘤引起的，如胰高血糖素瘤，其症状表现为坏死溶解性红斑、低氨基酸和高血糖。这种现象可单独或在多发性内分泌肿瘤I型环境下发生。

GCG, glucagon 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human GCG 分子靶点信息

  • 分子名：GCG, glucagon
  • 别称：
    • glicentin-related polypeptide
    • GLP-1
    • GLP1
    • GLP2
    • glucagon-like peptide 1
    • glucagon-like peptide 2
    • GRPP
    • preproglucagon
    • pro-glucagon
  • 基因序列：NCBI_Gene: 2641
  • 蛋白序列：UniProtKB: P01275

人 Human GCG靶点分子功能（预测）

Enables gastric inhibitory polypeptide receptor binding activity and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of bicellular tight junction assembly; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and protein kinase A signaling. Predicted to act upstream of or within negative regulation of execution phase of apoptosis; positive regulation of gluconeogenesis; and positive regulation of histone H3-K4 methylation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Implicated in Alzheimer's disease and prediabetes syndrome.

小鼠 Mouse Gcg 分子靶点信息

小鼠 Mouse Gcg 靶点分子功能（预测）

Predicted to enable identical protein binding activity and signaling receptor binding activity. Involved in several processes, including positive regulation of protein phosphorylation; positive regulation of transport; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including positive regulation of gluconeogenesis; positive regulation of histone H3-K4 methylation; and regulation of insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including brain; gut; and urogenital ridge. Human ortholog(s) of this gene implicated in Alzheimer's disease and prediabetes syndrome. Orthologous to human GCG (glucagon).

大鼠 Rat Gcg 分子靶点信息

大鼠 Rat Gcg 靶点分子功能（预测）

Enables glucagon receptor binding activity and hormone activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway; negative regulation of appetite; and response to L-arginine. Located in extracellular space. Human ortholog(s) of this gene implicated in Alzheimer's disease and prediabetes syndrome. Orthologous to human GCG (glucagon).

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