FST 靶点信息

FST 分子靶点信息概述

  • 分子名：FST, follistatin
  • 别名：FS

FST 分子靶点综述

卵泡抑素，又名激活素结合蛋白，在人类中由FST基因编码。卵泡抑素是一个自分泌糖蛋白，几乎在高等动物的所有组织中都表达。卵泡抑素由垂体前叶中的滤泡星形细胞(FS)产生。它的基本功能是结合和生物中和TGF-β超家族中的成员。人们目前正在研究卵泡激素，作为肌肉生长抑制素的拮抗剂，在调控小鼠肌肉生长中的作用。脊髓性肌萎缩的动物模型试验显示：通过增加某些核心肌群的肌肉可增加卵泡抑素的水平，进而增加预期寿命。另外，人们也在研究卵泡抑素与多囊卵巢综合征之间的关系。

FST, follistatin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FST 分子靶点信息

人 Human FST靶点分子功能（预测）

Enables activin binding activity and activin receptor antagonist activity. Involved in hematopoietic progenitor cell differentiation; negative regulation of activin receptor signaling pathway; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of hair follicle development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in polycystic ovary syndrome.

小鼠 Mouse Fst 分子靶点信息

小鼠 Mouse Fst 靶点分子功能（预测）

Predicted to enable activin binding activity; activin receptor antagonist activity; and heparan sulfate proteoglycan binding activity. Acts upstream of or within several processes, including BMP signaling pathway; animal organ development; and keratinocyte proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; embryo mesenchyme; and genitourinary system. Used to study lethal restrictive dermopathy. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin).

大鼠 Rat Fst 分子靶点信息

  • 分子名：Fst, follistatin
  • 别称：
    • activin-binding protein
    • FOL1
    • follistatin-A
    • FS
    • Fst-288
    • LOC686745
    • RATFOL1
    • similar to follistatin
  • 基因序列：NCBI_Gene: 24373
  • 蛋白序列：UniProtKB: P21674

大鼠 Rat Fst 靶点分子功能（预测）

Enables heparan sulfate proteoglycan binding activity. Predicted to be involved in hematopoietic progenitor cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; keratinocyte proliferation; and positive regulation of hair follicle development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin).

FST 分子产品列表

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