FGF21 靶点信息

FGF21 分子靶点信息概述

  • 分子名：FGF21, fibroblast growth factor 21
  • 基因家族：Fibroblast growth factor family

FGF21 分子靶点综述

成纤维细胞生长因子21(FGF-21)表达于很多组织中，包括肝脏、褐色脂肪组织、白色脂肪组织和胰腺，在小鼠中，循环的FGF-21来源于肝脏。FGF-21促进脂肪细胞吸收葡萄糖，但对其它类型的细胞没有作用。II型糖尿病(T2DM)患者的血清FGF-21显著上升，表明其在T2DM发病机理中的作用。升高的FGF-21也与非酒精性脂肪肝疾病的肝脏脂肪含量有关，与人BMI呈正相关，提示肥胖是对FGF-21耐受的结果。

FGF21, fibroblast growth factor 21 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FGF21 分子靶点信息

人 Human FGF21靶点分子功能（预测）

Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glucose import. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Biomarker of atherosclerosis; chronic kidney disease; and fatty liver disease.

小鼠 Mouse Fgf21 分子靶点信息

小鼠 Mouse Fgf21 靶点分子功能（预测）

Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; cerebellum; integumental system; limb; and skeleton. Orthologous to human FGF21 (fibroblast growth factor 21).

大鼠 Rat Fgf21 分子靶点信息

大鼠 Rat Fgf21 靶点分子功能（预测）

Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in several processes, including cellular response to glucagon stimulus; endothelial cell apoptotic process; and negative regulation of cell death. Located in extracellular space. Orthologous to human FGF21 (fibroblast growth factor 21).

FGF21 分子产品列表

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