FCGR3B 靶点信息

FCGR3B 分子靶点信息概述

  • 分子名：FCGR3B, Fc gamma receptor IIIb
  • 基因家族：CD molecules; Immunoglobulin like domain containing
  • 别名：CD16; CD16b; FcgammaRIIIb; FcRIIIb
  • 曾用名：FCGR3; FCG3
  • 全称：Fc fragment of IgG, low affinity IIIb, receptor for (CD16); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc fragment of IgG receptor IIIb

FCGR3B 分子靶点综述

CD16是一种糖基化磷脂酰肌醇锚链的细胞膜蛋白，低亲和力Fcγ 受体(FcγRIII)的组成部分。包括CD16a和CD16b两种亚型，结构上略有差异。CD16表达于NK细胞(只表达在成熟NK细胞，NK前体和幼稚NK细胞不表达)、一些T淋巴细胞、中性粒细胞和巨噬细胞。

FCGR3B, Fc gamma receptor IIIb 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FCGR3B 分子靶点信息

  • 分子名：FCGR3B, Fc gamma receptor IIIb
  • 别称：
    • CD16
    • CD16A
    • CD16b
    • Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
    • Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
    • Fc gamma receptor III-B
    • Fc gamma receptor IIIb
    • Fc-gamma receptor IIIb (CD 16)
    • fc-gamma RIII
    • fc-gamma RIII-beta
    • fc-gamma RIIIb
    • FCG3
    • FCGR3
    • FCGR3A
    • FCR-10
    • FCRIII
    • FCRIIIb
    • igG Fc receptor III-1
    • low affinity immunoglobulin gamma Fc region receptor III-B
  • 基因序列：NCBI_Gene: 2215
  • 蛋白序列：UniProtKB: O75015

人 Human FCGR3B靶点分子功能（预测）

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and regulation of immune response. Located in extracellular exosome.

小鼠 Mouse Fcgr4 分子靶点信息

  • 分子名：Fcgr4, Fc receptor, IgG, low affinity IV
  • 别称：
    • 4833442P21Rik
    • CD16-2
    • Fc fragment of IgG, low affinity IIIa, receptor
    • FcgammaRIV
    • Fcgr3a
    • RIKEN cDNA 4833442P21 gene
  • 基因序列：NCBI_Gene: 246256
  • 蛋白序列：

小鼠 Mouse Fcgr4 靶点分子功能（预测）

Enables IgE receptor activity and IgG receptor activity. Involved in neutrophil activation and positive regulation of bone resorption. Located in cell surface. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and immunodeficiency 20. Orthologous to human FCGR3A (Fc fragment of IgG receptor IIIa) and FCGR3B (Fc fragment of IgG receptor IIIb).

大鼠 Rat Fcgr3a 分子靶点信息

  • 分子名：Fcgr3a, Fc fragment of IgG receptor IIIa
  • 别称：
    • Fc fragment of IgG intermediate affinity IV receptor
    • Fc fragment of IgG, low affinity IIIa, receptor
    • Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
    • Fcgr4
    • LOC304966
    • transmembrane receptor FcgammaRIII-X
  • 基因序列：NCBI_Gene: 304966
  • 蛋白序列：

大鼠 Rat Fcgr3a 靶点分子功能（预测）

Predicted to enable IgE receptor activity and IgG receptor activity. Involved in cellular response to lipopolysaccharide; regulation of sensory perception of pain; and wound healing. Located in cell surface. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and immunodeficiency 20. Orthologous to several human genes including FCGR3A (Fc fragment of IgG receptor IIIa).

FCGR3B 分子产品列表

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