FCGR2B, CD32 分子靶点信息

FCGR2B, CD32 分子靶点信息概述

  • 分子名：FCGR2B, Fc gamma receptor IIb
  • 基因家族：Fc receptors; CD molecules; Immunoglobulin like domain containing
  • 别名：FCG2; FCGR2; CD32; CD32B; FcgammaRIIb; FcGRIIB
  • 全称：Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG receptor IIb

FCGR2B, CD32 分子靶点综述

Fc受体表达于某些细胞表面，包括B细胞、NK细胞、巨噬细胞、中性粒细胞和肥大细胞，对免疫系统具有保护功能。CD16(FcγIII受体)和CD32(FcγII受体)对小鼠IgGFc片段具有低亲和力，表达于B细胞、单核/巨噬细胞、NK细胞、肥大细胞、中性粒细胞、未成熟的胸腺细胞和某些活化的成熟T细胞。

FCGR2B, CD32 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FCGR2B, CD32 分子靶点信息

  • 分子名：FCGR2B, Fc gamma receptor IIb
  • 别称：
    • CD32
    • CD32B
    • CDw32
    • Fc fragment of IgG receptor IIb
    • Fc fragment of IgG, low affinity II, receptor for (CD32)
    • Fc fragment of IgG, low affinity IIb, receptor (CD32)
    • Fc fragment of IgG, low affinity IIb, receptor for (CD32)
    • Fc gamma RIIb
    • fc-gamma RII-b
    • Fc-gamma RII-c
    • fc-gamma-RIIb
    • Fc-gamma-RIIc
    • FCG2
    • FcgammaRIIb
    • FCGR2
    • FCGR2C
    • FcGRIIB
    • fcRII-b
    • FcRII-c
    • IGFR2
    • igG Fc receptor II-b
    • IgG Fc receptor II-c
    • low affinity immunoglobulin gamma Fc region receptor II-b
    • Low affinity immunoglobulin gamma Fc region receptor II-c
  • 基因序列：NCBI_Gene: 2213
  • 蛋白序列：UniProtKB: P31994

人 Human FCGR2B, CD32靶点分子功能（预测）

Enables IgG binding activity; amyloid-beta binding activity; and low-affinity IgG receptor activity. Involved in several processes, including Fc-gamma receptor signaling pathway involved in phagocytosis; negative regulation of B cell receptor signaling pathway; and regulation of dendritic spine maintenance. Located in plasma membrane. Implicated in autoimmune thrombocytopenic purpura; glomerulonephritis; lymphoid leukemia; malaria; and systemic lupus erythematosus. Biomarker of end stage renal disease.

小鼠 Mouse FCGR2B, CD32 分子靶点信息

  • 分子名：Fcgr2b, Fc receptor, IgG, low affinity IIb
  • 别称：
    • AI528646
    • CD32
    • expressed sequence AI528646
    • F630109E10Rik
    • Fc gamma RIIB
    • Fc receptor, IgG, low affinity II
    • Fc receptor, IgG, low affinity IIa
    • Fc-gamma receptor 2
    • Fc-gamma receptor 3
    • Fc[g]RII
    • FcgammaRIIB
    • Fcgr2
    • Fcgr2a
    • FcgRII
    • Fcr-2
    • Fcr-3
    • Ly-17
    • Ly-m20
    • LyM-1
    • Lym-1
    • lymphocyte antigen 17
    • lymphocyte antigen m20
    • RIKEN cDNA F630109E10 gene
  • 基因序列：NCBI_Gene: 14130
  • 蛋白序列：

小鼠 Mouse FCGR2B, CD32 靶点分子功能（预测）

Enables IgG binding activity. Involved in several processes, including Fc receptor-mediated immune complex endocytosis; nervous system development; and regulation of cellular response to stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is expressed in liver and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc gamma receptor IIb).

大鼠 Rat FCGR2B, CD32 分子靶点信息

  • 分子名：FCGR2B, Fc gamma receptor 2B
  • 别称：
    • CD32
    • Fc fragment of IgG receptor IIb
    • Fc fragment of IgG, low affinity IIb, receptor
    • Fc gamma receptor IIb
    • Fc receptor, IgG, low affinity IIb
    • FC-gamma RII
    • FcgammaRIIB2
    • Fcgr2
    • FCRII
    • igG Fc receptor II beta
    • low affinity immunoglobulin gamma Fc region receptor II
    • low affinity immunoglobulin gamma FC region receptor II precursor
    • low affinity immunoglobulin gamma Fc region receptor II-b
  • 基因序列：NCBI_Gene: 289211
  • 蛋白序列：

大鼠 Rat FCGR2B, CD32 靶点分子功能（预测）

Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to lipopolysaccharide; and negative regulation of neutrophil apoptotic process. Located in cell surface; membrane raft; and recycling endosome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc gamma receptor IIb).

FCGR2B, CD32 分子产品列表

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