FASLG 靶点信息

FASLG 分子靶点信息概述

  • 分子名：FASLG, Fas ligand
  • 基因家族：CD molecules; Tumor necrosis factor superfamily; Death inducing signaling complex
  • 别名：FasL; CD178
  • 曾用名：APT1LG1; TNFSF6
  • 全称：tumor necrosis factor (ligand) superfamily, member 6; Fas ligand (TNF superfamily, member 6)

FASLG 分子靶点综述

Fas配体，又名TNFSF6、FasL或CD95L，是肿瘤坏死因子(TNF)家族中的一员。它是一个在细胞毒性T淋巴细胞上表达的同源三聚体II型跨膜蛋白。外基质金属蛋白酶MMP-7在保守裂解位点裂解膜结合的FasL可生成可溶性Fas配体。Fas配体/受体的相互作用在调节免疫系统和癌症的进展中发挥重要作用。它通过FasR的三聚体化产生信号，这个三聚体化通常会导致细胞凋亡或死亡。由Fas-Fas配体结合所引起的凋亡在免疫系统的调节中发挥至关重要的作用，它的功能包括T细胞稳态、细胞毒性T细胞活性、免疫特权、母体耐受性和肿瘤反击。有缺陷的Fas介导的细胞凋亡可导致肿瘤的发生和现有肿瘤的耐药性。Fas基因突变与自身免疫性淋巴增生综合征(ALPS)相关。

FASLG, Fas ligand 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human FASLG 分子靶点信息

  • 分子名：FASLG, Fas ligand
  • 别称：
    • ALPS1B
    • apoptosis (APO-1) antigen ligand 1
    • apoptosis antigen ligand
    • APT1LG1
    • APTL
    • CD178
    • CD95 ligand
    • CD95-L
    • CD95L
    • fas antigen ligand
    • Fas ligand (TNF superfamily, member 6)
    • FASL
    • mutant tumor necrosis factor family member 6
    • TNFSF6
    • TNLG1A
    • tumor necrosis factor (ligand) superfamily, member 6
    • tumor necrosis factor ligand 1A
    • tumor necrosis factor ligand superfamily member 6
  • 基因序列：NCBI_Gene: 356
  • 蛋白序列：UniProtKB: P48023

人 Human FASLG靶点分子功能（预测）

Predicted to enable signaling receptor binding activity. Involved in several processes, including necroptotic signaling pathway; positive regulation of endothelial cell apoptotic process; and positive regulation of phosphatidylserine exposure on apoptotic cell surface. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of apoptotic process; and release of sequestered calcium ion into cytosol by endoplasmic reticulum. Located in extracellular exosome; nucleus; and plasma membrane. Implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; pancreatic cancer (multiple); pre-eclampsia (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including bone marrow cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; clonorchiasis; and neurodegenerative disease (multiple).

小鼠 Mouse Fasl 分子靶点信息

小鼠 Mouse Fasl 靶点分子功能（预测）

Predicted to enable death receptor binding activity and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).

大鼠 Rat Faslg 分子靶点信息

  • 分子名：Faslg, Fas ligand
  • 别称：
    • apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)
    • Apt1Lg1
    • CD95 ligand
    • CD95-L
    • CD95L protein
    • Fas antigen ligand
    • Fas ligand (TNF superfamily, member 6)
    • Fasl
    • Tnfsf6
    • Tnlg1a
    • Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
    • tumor necrosis factor (ligand) superfamily, member 6
    • Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
    • tumor necrosis factor ligand 1a
    • tumor necrosis factor ligand superfamily member 6
  • 基因序列：NCBI_Gene: 25385
  • 蛋白序列：

大鼠 Rat Faslg 靶点分子功能（预测）

Enables death receptor binding activity and tumor necrosis factor receptor binding activity. Involved in several processes, including cellular ion homeostasis; cellular response to interferon-gamma; and extrinsic apoptotic signaling pathway via death domain receptors. Located in caveola; cytoplasmic vesicle; and perinuclear region of cytoplasm. Used to study brain glioma; substance-related disorder; and type 1 diabetes mellitus. Biomarker of several diseases, including artery disease (multiple); chronic obstructive pulmonary disease; gastric ulcer; liver disease (multiple); and ulcerative colitis. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand).

FASLG 分子产品列表

FASLG 分子靶点最新资讯

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