F9 分子靶点信息 - F9分子别称 | 人/小鼠/大鼠F9分子靶点功能 | F9分子靶点检测

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F9 分子靶点信息概述
F9 分子靶点综述
F9, coagulation factor IX 分子靶点种属信息
F9 分子产品列表
Human Coagulation Factor IX/ FIX/F9 Standard (人凝血因子IX 标准品)
Human Coagulation Factor IX/FIX/F9 ELISA Kit检测试剂盒（酶联免疫吸附法）
F9 分子靶点最新资讯

F9 分子靶点信息概述

分子名：F9, coagulation factor IX
基因家族：Gla domain containing
别名：FIX
全称：Factor IX; plasma thromboplastic component; Christmas disease; hemophilia B

F9 分子靶点综述

凝血因子IX，又名FIX和F9，是一种丝氨酸蛋白酶，属于肽酶家族S1。F9作为一种酶原、非活性前体被产生，接着进行一系列的加工过程—去除信号肽、糖基化，然后被因子XIa或因子VIIa裂解成一个由二硫键连接的双链形式。抗凝血酶可抑制F9。另外，在人类和小鼠中，F9的表达量随着年龄的增加而增加。缺乏F9会导致B型血友病的发生。在超过100个F9突变体中，一些不引起任何症状，但是许多会引发明显的出血障碍。重组F9可用于治疗B型血友病，市面上的商品有BeneFIX和Alprolix。一些罕见的F9突变会导致凝血活性升高，导致凝血疾病，如深部静脉血栓形成。先天缺乏F9的患者在进行外科手术时，氨甲环酸可能会降低其围手术期的出血风险。

F9, coagulation factor IX 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human F9 分子靶点信息

分子名：F9, coagulation factor IX
别称：
- Christmas factor
- coagulation factor 9
- coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
- F9 p22
- factor 9
- factor IX F9
- FIX
- FIX F9
- HEMB
- MGC129641
- MGC129642
- P19
- plasma thromboplastic component
- plasma thromboplastin component
- PTC
- serine protease
- THPH8
基因序列：NCBI_Gene: 2158
蛋白序列：UniProtKB: P00740

人 Human F9靶点分子功能（预测）

Enables calcium ion binding activity and endopeptidase activity. Involved in blood coagulation and zymogen activation. Located in extracellular space. Part of collagen-containing extracellular matrix. Implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Biomarker of type 2 diabetes mellitus.

小鼠 Mouse F9 分子靶点信息

分子名：F9, coagulation factor IX
别称：
- AW111646
- Cf-9
- Cf9
- expressed sequence AW111646
基因序列：NCBI_Gene: 14071
蛋白序列：
- UniprotKB: P16294
- UniprotKB: A0JLY3

小鼠 Mouse F9 靶点分子功能（预测）

Enables peptidase activity. Acts upstream of or within blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo and liver. Used to study hemophilia B. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Orthologous to human F9 (coagulation factor IX).

大鼠 Rat F9 分子靶点信息

分子名：F9, coagulation factor IX
别称：
- christmas factor
- coagulation factor 9
- Coagulation factor IX (plasma thromboplastic component Christmas disease hemophilia B)
- Coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)
基因序列：NCBI_Gene: 24946
蛋白序列：UniProtKB: P16296

大鼠 Rat F9 靶点分子功能（预测）

Predicted to enable calcium ion binding activity and endopeptidase activity. Involved in blood coagulation. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in X-linked thrombophilia due to factor IX defect; X-linked warfarin sensitivity; and hemophilia B. Orthologous to human F9 (coagulation factor IX).