EGFR 靶点信息

EGFR 分子靶点信息概述

  • 分子名：EGFR, epidermal growth factor receptor
  • 基因家族：Erb-b2 receptor tyrosine kinases
  • 别名：ERBB1; ERRP
  • 曾用名：ERBB
  • 全称：erythroblastic leukemia viral (v-erb-b) oncogene homolog (avian); erb-b2 receptor tyrosine kinase 1; epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)

EGFR 分子靶点综述

表皮生长因子受体(EGFR)，又名ErbB1和HER1，是一个I型跨膜糖蛋白。它存在于细胞表面，靠与它的特定配体包括EGF和TGF-α结合来激活。EGFR信号在调节细胞增殖、存活和分化过程中起重要作用。EGFR与配体结合后就会诱导其发生同源或异源二聚体化，进而引发后续的酪氨酸自磷酸化和多种下游通路(MAPK、PI3K/PKB和STAT)。该受体激活在人类皮肤的先天性免疫应答中有重要作用，EGFR过表达(上调)或活性过度增加与许多癌症，包括肺癌、肛门癌和多形性胶质母细胞瘤有关。异常的EGFR信号与牛皮癣、湿疹和动脉粥样硬化有关，目前，研究者认为EGFR可作为癌症治疗的一个靶标。

EGFR, epidermal growth factor receptor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human EGFR 分子靶点信息

  • 分子名：EGFR, epidermal growth factor receptor
  • 别称：
    • avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
    • cell growth inhibiting protein 40
    • cell proliferation-inducing protein 61
    • EGFR vIII
    • epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
    • epidermal growth factor receptor tyrosine kinase domain
    • erb-b2 receptor tyrosine kinase 1
    • ERBB
    • ERBB1
    • ERRP
    • erythroblastic leukemia viral (v-erb-b) oncogene homolog
    • HER1
    • mENA
    • NISBD2
    • PIG61
    • proto-oncogene c-ErbB-1
    • receptor tyrosine-protein kinase erbB-1
  • 基因序列：NCBI_Gene: 1956
  • 蛋白序列：UniProtKB: P00533

人 Human EGFR靶点分子功能（预测）

Enables several functions, including actin filament binding activity; enzyme binding activity; and epidermal growth factor-activated receptor activity. Contributes to nitric-oxide synthase regulator activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of intracellular signal transduction; and regulation of protein metabolic process. Acts upstream of or within epidermal growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; endosome; and membrane raft. Part of receptor complex. Is active in ruffle membrane. Colocalizes with endosome. Implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Biomarker of several diseases, including Human papillomavirus infectious disease; breast cancer (multiple); carcinoma (multiple); chronic obstructive pulmonary disease; and pulmonary hypertension.

小鼠 Mouse Egfr 分子靶点信息

小鼠 Mouse Egfr 靶点分子功能（预测）

Enables epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in cellular response to amino acid stimulus and positive regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; epidermal growth factor receptor signaling pathway; and protein autophosphorylation. Located in several cellular components, including basolateral plasma membrane; endocytic vesicle; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; limb; and respiratory system. Used to study Coronavirus infectious disease and aortic valve disease. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).

大鼠 Rat Egfr 分子靶点信息

大鼠 Rat Egfr 靶点分子功能（预测）

Enables several functions, including calmodulin binding activity; epidermal growth factor binding activity; and epidermal growth factor-activated receptor activity. Involved in several processes, including animal organ development; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Used to study bronchiolo-alveolar adenocarcinoma; dilated cardiomyopathy; and high grade glioma. Biomarker of several diseases, including Parkinsonism; acute kidney failure; lung disease (multiple); median neuropathy; and peptic esophagitis. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).

EGFR 分子产品列表

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