EFNA1 靶点信息

EFNA1 分子靶点信息概述

  • 分子名：EFNA1, ephrin A1
  • 基因家族：Ephrins
  • 别名：LERK1; ECKLG; GMAN
  • 曾用名：TNFAIP4; EPLG1
  • 全称：EPH-related receptor tyrosine kinase ligand 1; Tumor necrosis factor alpha-induced protein 4; gastric cancer metastasis associated long noncoding RNA; ephrin-A1

EFNA1 分子靶点综述

Ephrin-A1，又名EFNA1，在人类中由EFNA1基因编码，该基因编码Eph家族成员。ephrins和Eph相关受体组成了最大的受体酪氨酸激酶亚家族，参与调节神经和造血系统的发展。根据它们的结构和序列关系，ephrins可分为ephrin-A(EFNA)类和ephrin-B(EFNB)类。Ephrin-A配体结合EphA受体，通过糖基磷脂酰肌醇(GPI)连接锚定到质膜上。而ephrin-B配体结合EphB受体，通过跨膜结构域锚定到质膜上。Ephrin-A1及它的其中之一受体EphA2在异种移植的内皮细胞和肿瘤细胞中表达，在某种程度上可通过影响肿瘤新血管形成，从而在人类癌症中发挥作用。

EFNA1, ephrin A1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human EFNA1 分子靶点信息

  • 分子名：EFNA1, ephrin A1
  • 别称：
    • B61
    • ECKLG
    • EFL1
    • eph-related receptor tyrosine kinase ligand 1
    • ephrin-A1
    • EPLG1
    • gastric cancer metastasis associated long noncoding RNA
    • GMAN
    • immediate early response protein B61
    • LERK-1
    • LERK1
    • ligand of eph-related kinase 1
    • TNF alpha-induced protein 4
    • TNFAIP4
    • tumor necrosis factor alpha-induced protein 4
    • tumor necrosis factor, alpha-induced protein 4
  • 基因序列：NCBI_Gene: 1942
  • 蛋白序列：UniProtKB: P20827

人 Human EFNA1靶点分子功能（预测）

Enables ephrin receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; protein stabilization; and regulation of protein metabolic process. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Predicted to be anchored component of plasma membrane.

小鼠 Mouse Efna1 分子靶点信息

小鼠 Mouse Efna1 靶点分子功能（预测）

Enables ephrin receptor binding activity. Involved in several processes, including heart valve morphogenesis; negative regulation of dendritic spine morphogenesis; and regulation of blood vessel endothelial cell migration. Acts upstream of or within several processes, including ephrin receptor signaling pathway; nervous system development; and regulation of MAPK cascade. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human EFNA1 (ephrin A1).

大鼠 Rat Efna1 分子靶点信息

  • 分子名：Efna1, ephrin A1
  • 别称：
    • B61
    • EPH-related receptor tyrosine kinase ligand 1
    • ephrin-A1
    • immediate early response protein B61
    • LERK-1
  • 基因序列：NCBI_Gene: 94268
  • 蛋白序列：UniProtKB: P97553

大鼠 Rat Efna1 靶点分子功能（预测）

Predicted to enable ephrin receptor binding activity. Predicted to be involved in several processes, including cell morphogenesis involved in differentiation; heart valve morphogenesis; and regulation of protein metabolic process. Predicted to act upstream of or within several processes, including negative regulation of thymocyte apoptotic process; nervous system development; and regulation of MAPK cascade. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Predicted to be anchored component of plasma membrane. Orthologous to human EFNA1 (ephrin A1).

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