EDN1 靶点信息

EDN1 分子靶点信息概述

  • 分子名：EDN1, endothelin 1
  • 基因家族：Endothelins
  • 别名：ET1

EDN1 分子靶点综述

内皮素-1(ET-1)是由21个氨基酸残基组成的多肽，是一种多效性分，它最初是212个氨基酸的前多肽原。血管内皮细胞是ET-1的丰富来源。内皮细胞中的ET-1的表达受多种因素的影响，包括机械刺激、多种激素和促炎性细胞因子。内皮素首先被鉴定为内皮素衍生的舒张因子，然后又被鉴定为内皮素衍生的收缩因子。ET-1刺激心肌收缩和心肌细胞生长，调节血管活性物质的释放，刺激平滑肌细胞有丝分裂。它也作为内皮细胞的促生因子，由下丘脑和垂体细胞调节其分泌。ET-1可能通过促进中性粒细胞的粘附和迁移以及刺激促炎细胞因子的产生来控制炎症反应。

EDN1, endothelin 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human EDN1 分子靶点信息

  • 分子名：EDN1, endothelin 1
  • 别称：
    • ARCND3
    • endothelin-1
    • ET1
    • HDLCQ7
    • PPET1
    • preproendothelin-1
    • QME
  • 基因序列：NCBI_Gene: 1906
  • 蛋白序列：UniProtKB: P05305

人 Human EDN1靶点分子功能（预测）

Enables signaling receptor binding activity. Involved in several processes, including intracellular signal transduction; regulation of macromolecule biosynthetic process; and vascular associated smooth muscle contraction. Located in cytoplasm and extracellular space. Implicated in several diseases, including artery disease (multiple); bronchial disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); glaucoma (multiple); lung disease (multiple); and retinal disease (multiple).

小鼠 Mouse Edn1 分子靶点信息

小鼠 Mouse Edn1 靶点分子功能（预测）

Enables endothelin A receptor binding activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; animal organ development; and rhythmic excitation. Located in extracellular space. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; gut; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung disease (multiple); obesity; obstructive sleep apnea; and rheumatoid arthritis. Orthologous to human EDN1 (endothelin 1).

大鼠 Rat Edn1 分子靶点信息

  • 分子名：Edn1, endothelin 1
  • 别称：
    • dickkopf 1 homolog
    • dickkopf 1 homolog (Xenopus laevis)
    • dickkopf homolog 1
    • dickkopf homolog 1 (Xenopus laevis)
    • dickkopf-like protein 1
    • dickkopf-related protein 1
    • LOC293897
    • NEWGENE_1307313
  • 基因序列：NCBI_Gene: 24323
  • 蛋白序列：UniProtKB: P22388

大鼠 Rat Edn1 靶点分子功能（预测）

Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in negative regulation of ossification and positive regulation of neuron death. Located in extracellular space. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).

EDN1 分子产品列表

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