DKK1 靶点信息

DKK1 分子靶点信息概述

  • 分子名：DKK1, dickkopf WNT signaling pathway inhibitor 1
  • 别名：SK; DKK-1
  • 全称：dickkopf (Xenopus laevis) homolog 1; dickkopf 1 homolog (Xenopus laevis)

DKK1 分子靶点综述

Dickkopf相关蛋白1(Dkk-1)是一种分泌蛋白，含有2个富含半胱氨酸区域，通过其对Wnt信号通路的抑制，参与胚胎发育。所有Dkk-1敲除的纯合子小鼠在出生时都已死亡，这是由于头盖骨和神经嵴的结构有缺陷而导致的，如眼睛、嗅基板、额鼻、下颌等无法发育，以及前脑和中脑发育不完全、前肢的足趾融合。骨髓、血浆和外周血中的Dkk-1表达量提高与多发性骨髓瘤患者的溶骨性病变有关。

DKK1, dickkopf WNT signaling pathway inhibitor 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human DKK1 分子靶点信息

  • 分子名：DKK1, dickkopf WNT signaling pathway inhibitor 1
  • 别称：
    • dickkopf 1 homolog
    • dickkopf related protein-1
    • dickkopf-1 like
    • dickkopf-like protein 1
    • dickkopf-related protein 1
    • DKK-1
    • hDkk-1
    • SK
  • 基因序列：NCBI_Gene: 22943
  • 蛋白序列：UniProtKB: O94907

人 Human DKK1靶点分子功能（预测）

Enables co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including regulation of cell fate specification; regulation of gene expression; and regulation of protein phosphorylation. Located in extracellular space and plasma membrane. Implicated in anodontia.

小鼠 Mouse Dkk1 分子靶点信息

小鼠 Mouse Dkk1 靶点分子功能（预测）

Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of cellular component organization; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including Wnt signaling pathway involved in somitogenesis; embryonic morphogenesis; and negative regulation of signal transduction. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).

大鼠 Rat Dkk1 分子靶点信息

  • 分子名：Dkk1, dickkopf WNT signaling pathway inhibitor 1
  • 别称：
    • dickkopf 1 homolog
    • dickkopf 1 homolog (Xenopus laevis)
    • dickkopf homolog 1
    • dickkopf homolog 1 (Xenopus laevis)
    • dickkopf-like protein 1
    • dickkopf-related protein 1
    • LOC293897
    • NEWGENE_1307313
  • 基因序列：NCBI_Gene: 293897
  • 蛋白序列：UniProtKB: D3Z9J1

大鼠 Rat Dkk1 靶点分子功能（预测）

Predicted to enable co-receptor binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Involved in negative regulation of ossification and positive regulation of neuron death. Located in extracellular space. Used to study visual epilepsy. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).

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