DCN 靶点信息

DCN 分子靶点信息概述

  • 分子名：DCN, decorin
  • 基因家族：Small leucine rich repeat proteoglycans
  • 别名：DSPG2; SLRR1B
  • 全称：decorin proteoglycan

DCN 分子靶点综述

Decorin（核心蛋白聚糖）是富含亮氨酸低分子蛋白聚糖（SLRP）家族的一种分泌蛋白聚糖。Decorin调节细胞外胶原基质以及基质相关生长因子FGF、GDF-8 / Myostatin、TGF-beta和WISP-1的生物活性。它还结合并激活EGF受体、ErbB4和IGF-1受体。Decorin促进成肌细胞分化，支持血管生成并抑制肿瘤发展。有研究表明，Decorin可能对增生性瘢痕的挛缩具有抑制作用,表明在预防增生性瘢痕形成和促进瘢痕的成熟中具有一定的作用。

DCN, decorin 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human DCN 分子靶点信息

  • 分子名：DCN, decorin
  • 别称：
    • bone proteoglycan II
    • CSCD
    • decorin proteoglycan
    • dermatan sulphate proteoglycans II
    • DSPG2
    • PG-S2
    • PG40
    • PGII
    • PGS2
    • proteoglycan core protein
    • SLRR1B
    • small leucine-rich protein 1B
  • 基因序列：NCBI_Gene: 1634
  • 蛋白序列：UniProtKB: P07585

人 Human DCN靶点分子功能（预测）

Enables RNA binding activity. Involved in positive regulation of autophagy. Acts upstream of or within several processes, including positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; and regulation of signal transduction. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Biomarker of gestational diabetes and type 2 diabetes mellitus.

小鼠 Mouse Dcn 分子靶点信息

小鼠 Mouse Dcn 靶点分子功能（预测）

Enables extracellular matrix binding activity and glycosaminoglycan binding activity. Acts upstream of or within peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Ehlers-Danlos syndrome and congenital stromal corneal dystrophy. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin).

大鼠 Rat Dcn 分子靶点信息

  • 分子名：Dcn, decorin
  • 别称：
    • bone proteoglycan II
    • dermatan sulfate proteoglycan-II (decorin)
    • DSPG
    • MGC94682
    • PG-S2
    • PG40
  • 基因序列：NCBI_Gene: 29139
  • 蛋白序列：UniProtKB: Q01129

大鼠 Rat Dcn 靶点分子功能（预测）

Enables collagen binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; response to lipopolysaccharide; and wound healing. Located in extracellular matrix. Part of collagen type VI trimer. Biomarker of asthma; myocardial infarction; and obesity. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin).

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