CXCL9 靶点信息

CXCL9 分子靶点信息概述

  • 分子名：CXCL9, C-X-C motif chemokine ligand 9
  • 基因家族：Chemokine ligands
  • 别名：SCYB9; Humig; crg-10
  • 曾用名：CMK; MIG
  • 全称：monokine induced by gamma interferon; chemokine (C-X-C motif) ligand 9

CXCL9 分子靶点综述

趋化因子CXC配体9(CXCL9)，又名γ干扰素诱导的单核因子(MIG)，是属于CXC趋化因子家族的一个小分子量细胞因子。它与其它两个CXC趋化因子CXCL10和CXCL11密切相关，它们都是与趋化因子受体CXCR3相互作用来发挥其趋化功能。CXCL9参与Th1型炎症，它有许多功能，主要的功能是化学吸引。活化的B细胞、单核细胞、CD8+记忆性T细胞和CD4+Th1T细胞都可对CXCL9作出应答。CXCL9还可通过作为IL-4/Th2应答的拮抗剂来促进Th1应答，这是通过阻断Th2相关趋化因子(eotaxin)发生的，从而限制Th2的浸润。CXCL9还可通过其延伸的C端展现出直接的抗微生物活性。在造血中，CXCL9参与CD34+干细胞的动员和迁移、抑制红系和髓系细胞集落的形成。

CXCL9, C-X-C motif chemokine ligand 9 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CXCL9 分子靶点信息

  • 分子名：CXCL9, C-X-C motif chemokine ligand 9
  • 别称：
    • C-X-C motif chemokine 9
    • chemokine (C-X-C motif) ligand 9
    • CMK
    • crg-10
    • gamma-interferon-induced monokine
    • Humig
    • MIG
    • monokine induced by gamma interferon
    • monokine induced by interferon-gamma
    • SCYB9
    • small-inducible cytokine B9
  • 基因序列：NCBI_Gene: 4283
  • 蛋白序列：UniProtKB: Q07325

人 Human CXCL9靶点分子功能（预测）

Enables CXCR3 chemokine receptor binding activity and chemokine activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; antimicrobial humoral immune response mediated by antimicrobial peptide; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including chronic fatigue syndrome; cystic fibrosis; lung disease (multiple); severe acute respiratory syndrome; and thoracic aortic aneurysm.

小鼠 Mouse Cxcl9 分子靶点信息

小鼠 Mouse Cxcl9 靶点分子功能（预测）

Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Acts upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in central nervous system; retina; stomach; testis; and thymus. Orthologous to human CXCL9 (C-X-C motif chemokine ligand 9).

大鼠 Rat Cxcl9 分子靶点信息

  • 分子名：Cxcl9, C-X-C motif chemokine ligand 9
  • 别称：
    • C-X-C motif chemokine 9
    • chemokine (C-X-C motif) ligand 9
    • MGC105312
    • Mig
    • monokine induced by gamma interferon
    • Scyb9
    • small inducible cytokine B9
  • 基因序列：NCBI_Gene: 246759
  • 蛋白序列：UniProtKB: Q8K4B1

大鼠 Rat Cxcl9 靶点分子功能（预测）

Predicted to enable CXCR3 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including defense response to virus; positive regulation of myoblast differentiation; and positive regulation of myoblast fusion. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space. Orthologous to human CXCL9 (C-X-C motif chemokine ligand 9).

CXCL9 分子产品列表

CXCL9 分子靶点最新资讯

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