CXCL16 靶点信息

CXCL16 分子靶点信息概述

  • 分子名：CXCL16, C-X-C motif chemokine ligand 16
  • 基因家族：Chemokine ligands; Scavenger receptors
  • 别名：SR-PSOX; CXCLG16; SRPSOX
  • 全称：CXC chemokine ligand 16; chemokine (C-X-C motif) ligand 16

CXCL16 分子靶点综述

趋化因子(C-X-C 基序)配体 16(CXCL16)是属于 CXC 趋化因子家族的一种小分子量细胞因子， 由 254 个氨基酸组成，是一种 I 型膜蛋白。人类 CXCL16 的基因位于 17 号染色体上。CXCL16 是 由淋巴器官 T 细胞区内的树突状细胞和脾脏红髓内的细胞产生的。炎症细胞因子 IFN-γ和 TNF-α 可诱导 CXCL16 的表达。CXCL16 与趋化因子受体 CXCR6(也被称为 Bonzo)相互作用。注射叶酸 可迫使 CXCL 16 发生甲基化，诱导 CXCL 16 基因启动子在结肠、回肠和肺部产生高水平的甲基 化，同时也使 iNKT 细胞在这些组织中积聚。

CXCL16, C-X-C motif chemokine ligand 16 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CXCL16 分子靶点信息

  • 分子名：CXCL16, C-X-C motif chemokine ligand 16
  • 别称：
    • C-X-C motif chemokine 16
    • chemokine (C-X-C motif) ligand 16
    • CXC chemokine ligand 16
    • CXCLG16
    • scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
    • small-inducible cytokine B16
    • SR-PSOX
    • SRPSOX
    • transmembrane chemokine CXCL16
  • 基因序列：NCBI_Gene: 58191
  • 蛋白序列：UniProtKB: Q9H2A7

人 Human CXCL16靶点分子功能（预测）

Enables chemokine activity. Involved in several processes, including positive regulation of cell growth; response to interferon-gamma; and response to tumor necrosis factor. Located in extracellular space. Biomarker of COVID-19 and systemic scleroderma.

小鼠 Mouse Cxcl16 分子靶点信息

小鼠 Mouse Cxcl16 靶点分子功能（预测）

Enables chemokine activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Involved in T cell chemotaxis and cellular response to lipopolysaccharide. Located in extracellular space. Is integral component of membrane. Is expressed in bladder; female associated reproductive structure; hindbrain meninges; male associated reproductive structure; and spinal cord meninges. Orthologous to human CXCL16 (C-X-C motif chemokine ligand 16).

大鼠 Rat Cxcl16 分子靶点信息

大鼠 Rat Cxcl16 靶点分子功能（预测）

Predicted to enable chemokine activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Predicted to be involved in several processes, including T cell chemotaxis; cellular response to lipopolysaccharide; and response to interferon-gamma. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human CXCL16 (C-X-C motif chemokine ligand 16).

CXCL16 分子产品列表

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