CXCL13 靶点信息

CXCL13 分子靶点信息概述

  • 分子名：CXCL13, C-X-C motif chemokine ligand 13
  • 基因家族：Chemokine ligands
  • 别名：BLC; BCA-1; BLR1L; ANGIE; ANGIE2
  • 曾用名：SCYB13
  • 全称：B-cell chemoattractant; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); chemokine (C-X-C motif) ligand 13

CXCL13 分子靶点综述

趋化因子CXC配体13(CXCL13)也称为B淋巴细胞趋化因子(BLC)或BCA-1，高水平表达于人的肝脏、脾脏、淋巴结和肠道中。它选择性地对属于B-1和B-2亚群的B细胞产生趋化作用，通过与趋化因子受体CXCR5作用展现其功能。CXCL13与其受体CXCR5调控淋巴组织滤泡中的B细胞构架。在T细胞中，CXCL13的表达被认为反映了T细胞，尤其是滤泡辅助性T细胞(Tfh)生发中心的起源。因此CXCL13在T细胞淋巴瘤中的表达，如血管免疫母细胞性T细胞淋巴瘤，被认为反映了肿瘤T细胞生发中心的起源。

CXCL13, C-X-C motif chemokine ligand 13 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CXCL13 分子靶点信息

  • 分子名：CXCL13, C-X-C motif chemokine ligand 13
  • 别称：
    • ANGIE
    • ANGIE2
    • b cell-attracting chemokine 1
    • b lymphocyte chemoattractant
    • B-cell chemoattractant
    • B-cell-attracting chemokine 1
    • B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1)
    • B-lymphocyte chemoattractant
    • BCA-1
    • BCA1
    • BLC
    • BLR1L
    • C-X-C motif chemokine 13
    • chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant)
    • CXC chemokine BLC
    • SCYB13
    • small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
    • small-inducible cytokine B13
  • 基因序列：NCBI_Gene: 10563
  • 蛋白序列：UniProtKB: O43927

人 Human CXCL13靶点分子功能（预测）

Enables chemokine receptor binding activity; fibroblast growth factor binding activity; and heparin binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cell chemotaxis; and regulation of chemotaxis. Located in extracellular region.

小鼠 Mouse Cxcl13 分子靶点信息

小鼠 Mouse Cxcl13 靶点分子功能（预测）

Enables CXCR5 chemokine receptor binding activity and chemokine activity. Involved in several processes, including B cell chemotaxis across high endothelial venule; activation of GTPase activity; and lymph node development. Located in extracellular space. Is expressed in Peyer's patch; aorta; central nervous system; and retina. Orthologous to human CXCL13 (C-X-C motif chemokine ligand 13).

大鼠 Rat Cxcl13 分子靶点信息

  • 分子名：Cxcl13, C-X-C motif chemokine ligand 13
  • 别称：
    • C-X-C motif chemokine 13
    • chemokine (C-X-C motif) ligand 13
    • LOC498335
    • similar to Small inducible cytokine B13 precursor (CXCL13) (B lymphocyte chemoattractant) (CXC chemokine BLC)
  • 基因序列：NCBI_Gene: 498335
  • 蛋白序列：

大鼠 Rat Cxcl13 靶点分子功能（预测）

Predicted to enable chemokine receptor binding activity; fibroblast growth factor binding activity; and heparin binding activity. Predicted to be involved in several processes, including cell chemotaxis; regulation of chemotaxis; and response to bacterium. Predicted to act upstream of or within lymph node development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CXCL13 (C-X-C motif chemokine ligand 13).

CXCL13 分子产品列表

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