CXCL11 靶点信息

CXCL11 分子靶点信息概述

  • 分子名：CXCL11, C-X-C motif chemokine ligand 11
  • 基因家族：Chemokine ligands
  • 别名：H174; b-R1; I-TAC; IP-9
  • 曾用名：SCYB9B; SCYB11
  • 全称：small inducible cytokine subfamily B (Cys-X-Cys), member 11; chemokine (C-X-C motif) ligand 11

CXCL11 分子靶点综述

C-X-C 基序趋化因子 11 (CXCL11)，又名干扰素诱导的 T 细胞 α 趋化因子(I-TAC)，是 CXC 趋化因子家族中的小分子 量细胞因子。它的基因和许多其它 CXC 趋化因子家族成员一样都位于人类 4 号染色体上。它在外周血白细胞、胰腺和肝 脏中高度表达，在胸腺、脾和肺中中等程度表达，在小肠、胎盘和前列腺组织中低度表达。IFN-γ 和 IFN-β 可强烈诱导 CXCL11 基因的表达，而 IFN-α 对其的诱导作用较弱。CXCL11 通过与细胞表面趋化因子受体 CXCR3 相互作用来作用于靶细胞。CXCL11 趋化活化的 T 细胞。CXCL11 具有 血管生成抑制作用，参与过敏性接触性皮炎、动脉粥样硬化、蕈样肉芽肿(一种 T 细胞淋巴瘤)和免疫介导的中枢神经系统 失调，如多发性硬化症。

CXCL11, C-X-C motif chemokine ligand 11 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CXCL11 分子靶点信息

  • 分子名：CXCL11, C-X-C motif chemokine ligand 11
  • 别称：
    • b-R1
    • beta-R1
    • C-X-C motif chemokine 11
    • chemokine (C-X-C motif) ligand 11
    • H174
    • I-TAC
    • interferon gamma-inducible protein 9
    • interferon-inducible T-cell alpha chemoattractant
    • IP-9
    • IP9
    • MGC102770
    • SCYB11
    • SCYB9B
    • small inducible cytokine B11
    • small inducible cytokine subfamily B (Cys-X-Cys), member 11
    • small inducible cytokine subfamily B (Cys-X-Cys), member 9B
    • small-inducible cytokine B11
  • 基因序列：NCBI_Gene: 6373
  • 蛋白序列：UniProtKB: O14625

人 Human CXCL11靶点分子功能（预测）

Enables CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Involved in several processes, including T cell chemotaxis; chemokine-mediated signaling pathway; and positive regulation of release of sequestered calcium ion into cytosol. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of bronchiolitis obliterans; chronic obstructive pulmonary disease; and pulmonary sarcoidosis.

小鼠 Mouse Cxcl11 分子靶点信息

小鼠 Mouse Cxcl11 靶点分子功能（预测）

Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; chemokine-mediated signaling pathway; and neutrophil chemotaxis. Predicted to be active in extracellular space. Is expressed in head; nasal cavity epithelium; palatal shelf epithelium; palatal shelf mesenchyme; and testis. Orthologous to human CXCL11 (C-X-C motif chemokine ligand 11).

大鼠 Rat Cxcl11 分子靶点信息

  • 分子名：Cxcl11, C-X-C motif chemokine ligand 11
  • 别称：
    • C-X-C motif chemokine 11
    • chemokine (C-X-C motif) ligand 11
    • SCYB11
  • 基因序列：NCBI_Gene: 305236
  • 蛋白序列：UniProtKB: Q7TNL0

大鼠 Rat Cxcl11 靶点分子功能（预测）

Enables chemokine activity. Involved in immune response. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human CXCL11 (C-X-C motif chemokine ligand 11).

CXCL11 分子产品列表

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