CXCL1 靶点信息

CXCL1 分子靶点信息概述

  • 分子名：CXCL1, C-X-C motif chemokine ligand 1
  • 基因家族：Chemokine ligands
  • 别名：SCYB1; GROa; MGSA-a; NAP-3
  • 曾用名：MGSA; GRO1; FSP
  • 全称：melanoma growth stimulating activity, alpha; GRO1 oncogene (melanoma growth stimulating activity, alpha); fibroblast secretory protein; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

CXCL1 分子靶点综述

趋化因子(C-X-C基序)配体1(CXCL1)是一个小分子量细胞因子，属于CXC趋化因子家族，以前又被称为GRO1致癌基因、GROα、KC和中性粒细胞激活蛋白3 (NAP-3)。在人类中，该蛋白由CXCL1基因编码。CXCL1由人类黑色素瘤细胞分泌，具有促有丝分裂特性，且与黑色素瘤发病机制有关。CXCL1由巨噬细胞、中性粒细胞和上皮细胞表达，有中性粒细胞趋化活性。该趋化因子通过趋化因子受体CXCR2产生信号，进而引发它的作用效果。CXCL1通过抑制少突细胞前体的迁移，从而对脊髓发育起作用。它参与血管生长、炎症、伤口愈合和肿瘤发生过程。小鼠的初步研究表明，CXCL1可降低多发性硬化症的严重程度，可提供神经保护作用。

CXCL1, C-X-C motif chemokine ligand 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CXCL1 分子靶点信息

  • 分子名：CXCL1, C-X-C motif chemokine ligand 1
  • 别称：
    • C-X-C motif chemokine 1
    • chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
    • fibroblast secretory protein
    • FSP
    • GRO-alpha(1-73)
    • GRO1
    • GRO1 oncogene (melanoma growth stimulating activity, alpha)
    • GRO1 oncogene (melanoma growth-stimulating activity)
    • GROa
    • growth-regulated alpha protein
    • melanoma growth stimulating activity, alpha
    • melanoma growth stimulatory activity alpha
    • MGSA
    • MGSA alpha
    • MGSA-a
    • NAP-3
    • neutrophil-activating protein 3
    • SCYB1
  • 基因序列：NCBI_Gene: 2919
  • 蛋白序列：UniProtKB: P09341

人 Human CXCL1靶点分子功能（预测）

Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in extracellular region; specific granule lumen; and tertiary granule lumen. Predicted to be active in extracellular space. Biomarker of asthma; chronic obstructive pulmonary disease; common cold; cystic fibrosis; and hyperhomocysteinemia.

小鼠 Mouse Cxcl1 分子靶点信息

小鼠 Mouse Cxcl1 靶点分子功能（预测）

Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in positive regulation of hematopoietic stem cell proliferation; positive regulation of neutrophil mediated killing of fungus; and positive regulation of superoxide anion generation. Located in extracellular space. Is expressed in several structures, including gonad; liver; lung; nervous system; and retina. Orthologous to human CXCL2 (C-X-C motif chemokine ligand 2).

大鼠 Rat Cxcl1 分子靶点信息

  • 分子名：Cxcl1, C-X-C motif chemokine ligand 1
  • 别称：
    • C-X-C motif chemokine 1
    • chemokine (C-X-C motif) ligand 1
    • chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
    • CINC-1
    • cytokine-induced neutrophil chemoattractant 1
    • Gro
    • Gro1
    • growth-regulated alpha protein
    • platelet-derived growth factor-inducible protein KC
  • 基因序列：NCBI_Gene: 81503
  • 蛋白序列：

大鼠 Rat Cxcl1 靶点分子功能（预测）

Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of ion transport; and response to amphetamine. Located in extracellular space. Biomarker of several diseases, including acute necrotizing pancreatitis; pneumonia (multiple); prostatitis; severe acute respiratory syndrome; and status epilepticus. Orthologous to human CXCL1 (C-X-C motif chemokine ligand 1); CXCL2 (C-X-C motif chemokine ligand 2); and CXCL3 (C-X-C motif chemokine ligand 3).

CXCL1 分子产品列表

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