文章目录[隐藏]
CX3CL1 分子靶点信息概述
- 分子名:CX3CL1, C-X3-C motif chemokine ligand 1
- 基因家族:Chemokine ligands
- 别名:NTN; C3Xkine; ABCD-3; CXC3C; CXC3
- 曾用名:SCYD1
- 全称:fractalkine; neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); chemokine (C-X3-C motif) ligand 1
CX3CL1 分子靶点综述
趋化因子(C-X3-C基序)配体1(CX3CL1),又名fractalkine,是一个由373个氨基酸组成的大分子细胞因子蛋白,也是CX3C趋化因子家族中唯一一个已知成员。可溶性CX3CL1存在于血清、尿液、脑脊液、羊水和滑液中,主要由血管内皮、平滑肌、神经元和树突状细胞表达。炎性细胞因子如TNF-α和IFN-γ可诱导大多数CX3CL1的表达。CX3CL1是通过与趋化因子受体CX3CR1的相互作用来发挥其粘附和迁移功能。可溶性CX3XL1可强烈趋化T细胞和单核细胞,而细胞结合的趋化因子促进白细胞强有力粘附到活化的内皮细胞上。CX3CL1可能与抗肿瘤活性有关,在消退正常炎症过程如伤口愈合中有重要作用。CX3CL1对某些条件的发病具有促进作用。
CX3CL1, C-X3-C motif chemokine ligand 1 分子靶点种属信息
人 Human CX3CL1 分子靶点信息
- 分子名:CX3CL1, C-X3-C motif chemokine ligand 1
- 别称:
- ABCD-3
- C-X3-C motif chemokine 1
- C3Xkine
- chemokine (C-X3-C motif) ligand 1
- CX3C membrane-anchored chemokine
- CXC3
- CXC3C
- fractalkine
- neurotactin
- NTN
- NTT
- SCYD1
- small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)
- small inducible cytokine subfamily D (Cys-X3-Cys), member-1
- small-inducible cytokine D1
- 基因序列:NCBI_Gene: 6376
- 蛋白序列:UniProtKB: P78423
人 Human CX3CL1靶点分子功能(预测)
Enables signaling receptor binding activity. Involved in several processes, including regulation of cell migration; regulation of gene expression; and regulation of signal transduction. Located in cell surface; extracellular region; and membrane. Is integral component of membrane. Implicated in Cor pulmonale and common cold. Biomarker of several diseases, including chronic fatigue syndrome; myositis (multiple); polyarteritis nodosa; pulmonary hypertension; and rheumatoid arthritis.
小鼠 Mouse Cx3cl1 分子靶点信息
- 分子名:Cx3cl1, chemokine (C-X3-C motif) ligand 1
- 别称:
- AB030188
- AI848747
- CX3C
- D8Bwg0439e
- DNA segment, Chr 8, Brigham & Women's Genetics 0439 expressed
- expressed sequence AI848747
- fractalkine
- hypothetical protein, clone 1-53
- neurotactin
- Scyd1
- small inducible cytokine subfamily D, 1
- 基因序列:NCBI_Gene: 20312
- 蛋白序列:
小鼠 Mouse Cx3cl1 靶点分子功能(预测)
Enables CX3C chemokine receptor binding activity and chemokine activity. Acts upstream of or within several processes, including angiogenesis involved in wound healing; leukocyte chemotaxis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is expressed in several structures, including brain; genitourinary system; gut; nose; and respiratory system. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1).
大鼠 Rat Cx3cl1 分子靶点信息
- 分子名:Cx3cl1, C-X3-C motif chemokine ligand 1
- 别称:
- C-X3-C motif chemokine 1
- chemokine (C-X3-C motif) ligand 1
- Cx3c
- CX3C membrane-anchored chemokine
- fractalkine
- neurotactin
- Scyd1
- small inducible cytokine subfamily D 1
- small inducible cytokine subfamily D, 1
- small-inducible cytokine D1
- 基因序列:NCBI_Gene: 89808
- 蛋白序列:
大鼠 Rat Cx3cl1 靶点分子功能(预测)
Enables chemokine activity. Involved in several processes, including positive regulation of cell population proliferation; regulation of gene expression; and regulation of signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and perinuclear region of cytoplasm. Used to study acute pancreatitis; ischemia; and status epilepticus. Biomarker of several diseases, including borna disease; brain disease (multiple); liver disease (multiple); lung disease (multiple); and pulmonary hypertension. Human ortholog(s) of this gene implicated in Cor pulmonale and common cold. Orthologous to human CX3CL1 (C-X3-C motif chemokine ligand 1).
CX3CL1 分子产品列表
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- EK1209
- ELISA试剂盒
Human CX3CL1/Fractalkine ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00