CTSD 靶点信息

CTSD 分子靶点信息概述

  • 分子名：CTSD, cathepsin D
  • 基因家族：Cathepsins; Peptidase family A1
  • 别名：CLN10
  • 曾用名：CPSD
  • 全称：ceroid-lipofuscinosis, neuronal 10; cathepsin D (lysosomal aspartyl protease)

CTSD 分子靶点综述

组织蛋白酶D是由CTSD基因编码的蛋白质。组织蛋白酶D是一种溶酶体天冬氨酰蛋白酶，在低pH下会被激活。它广泛存在于脊椎动物、真菌、反转录病毒和一些植物病毒中。通常情况下，组织蛋白酶D首先在糙面内质网中合成没有催化活性的前体酶原，去除信号肽后进入高尔基体进行蛋白的切割和加工，最终通过甘露糖-6-磷酸途径进入溶酶体中。在哺乳动物中，具有活性的成熟蛋白形式含有l条轻链和1条重链。组织蛋白酶D广泛表达，并参与蛋白水解降解，细胞侵袭和细胞凋亡。组织蛋白酶D基因的突变与几种疾病的发病机理有关，包括乳腺癌和可能的阿尔茨海默氏病在内的多种疾病，并且已被认为是乳腺癌的肿瘤标志物。

CTSD, cathepsin D 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CTSD 分子靶点信息

  • 分子名：CTSD, cathepsin D
  • 别称：
    • cathepsin d (lysosomal aspartyl protease)
    • ceroid-lipofuscinosis, neuronal 10
    • CLN10
    • CPSD
    • epididymis secretory sperm binding protein Li 130P
    • HEL-S-130P
    • lysosomal aspartyl peptidase
    • lysosomal aspartyl protease
    • MGC2311
  • 基因序列：NCBI_Gene: 1509
  • 蛋白序列：UniProtKB: P07339

人 Human CTSD靶点分子功能（预测）

Enables peptidase activity. Involved in several processes, including lipoprotein catabolic process; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in endosome membrane; lysosomal membrane; and membrane raft. Colocalizes with collagen-containing extracellular matrix. Implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Biomarker of Alzheimer's disease.

小鼠 Mouse Ctsd 分子靶点信息

小鼠 Mouse Ctsd 靶点分子功能（预测）

Enables aspartic-type endopeptidase activity. Acts upstream of or within autophagosome assembly. Located in extracellular space and lysosome. Is expressed in several structures, including central nervous system; extraembryonic component; eye; genitourinary system; and optic nerve. Used to study neuronal ceroid lipofuscinosis 10. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D).

大鼠 Rat Ctsd 分子靶点信息

大鼠 Rat Ctsd 靶点分子功能（预测）

Enables endopeptidase activity and peptide binding activity. Involved in proteolysis and response to nutrient levels. Located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Orthologous to human CTSD (cathepsin D).

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