COL18A1 靶点信息

COL18A1 分子靶点信息概述

  • 分子名：COL18A1, collagen type XVIII alpha 1 chain
  • 基因家族：Collagens; MicroRNA protein coding host genes
  • 别名：KS; KNO1
  • 曾用名：KNO
  • 全称：endostatin; Knobloch syndrome, type 1; collagen, type XVIII, alpha 1

COL18A1 分子靶点综述

内皮抑素是XVIII型胶原蛋白C末端非胶原（NC1）域的20 kDa蛋白水解片段，是一种内源性血管生成抑制剂。它最初被鉴定为鼠血管内皮细胞瘤细胞产生的因子，可以特异性抑制内皮细胞增殖和血管生成。在伤口愈合中，它抑制肿瘤生长并损害血管成熟。内皮抑素在内皮细胞粘附和细胞骨架组织中具有重要作用。它也可能参与诸如伤口愈合和胎盘循环建立等生理过程中的血管生成下调。内皮抑素的抗血管生成活性归因于其抑制内皮细胞增殖并抑制VEGF和FGF碱性诱导的内皮细胞迁移和粘附的能力。这些作用中的许多作用被认为是由内皮抑素与内皮细胞表达的转谷氨酰胺酶2，肝素和整合素α5 beta 1和αV beta 3之间的相互作用介导的。

COL18A1, collagen type XVIII alpha 1 chain 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human COL18A1 分子靶点信息

  • 分子名：COL18A1, collagen type XVIII alpha 1 chain
  • 别称：
    • antiangiogenic agent
    • collagen alpha-1(XVIII) chain
    • collagen alpha-1(XVIII) chain isoform 1 preproprotein
    • collagen type XVIII alpha 1
    • collagen, type XVIII, alpha 1
    • endostatin
    • FLJ27325
    • FLJ34914
    • GLCC
    • KNO
    • KNO1
    • Knobloch syndrome
    • KS
    • MGC74745
    • multi-functional protein MFP
  • 基因序列：NCBI_Gene: 80781
  • 蛋白序列：UniProtKB: P39060

人 Human COL18A1靶点分子功能（预测）

Enables identical protein binding activity. Predicted to be involved in angiogenesis; endothelial cell morphogenesis; and extracellular matrix organization. Predicted to act upstream of or within positive regulation of cell migration; positive regulation of cell population proliferation; and positive regulation of endothelial cell apoptotic process. Located in extracellular exosome. Colocalizes with collagen-containing extracellular matrix. Implicated in primary angle-closure glaucoma.

小鼠 Mouse Col18a1 分子靶点信息

小鼠 Mouse Col18a1 靶点分子功能（预测）

Predicted to enable identical protein binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including angiogenesis; endothelial cell morphogenesis; and positive regulation of endothelial cell apoptotic process. Located in basement membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to human COL18A1 (collagen type XVIII alpha 1 chain).

大鼠 Rat Col18a1 分子靶点信息

  • 分子名：Col18a1, collagen type XVIII alpha 1 chain
  • 别称：
    • collagen alpha-1(XVIII) chain
    • collagen type XVIII alpha 1
    • collagen, type XVIII, alpha 1
    • procollagen, type XVIII, alpha 1
  • 基因序列：NCBI_Gene: 85251
  • 蛋白序列：

大鼠 Rat Col18a1 靶点分子功能（预测）

Predicted to enable identical protein binding activity. Predicted to be an extracellular matrix structural constituent. Involved in response to hydrostatic pressure and response to xenobiotic stimulus. Located in extracellular space. Used to study hepatocellular carcinoma. Biomarker of gastric ulcer and ulcerative colitis. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to human COL18A1 (collagen type XVIII alpha 1 chain).

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