CNTF 靶点信息

CNTF 分子靶点信息概述

  • 分子名：CNTF, ciliary neurotrophic factor
  • 基因家族：Interleukin 6 type cytokine family
  • 别名：HCNTF
  • 全称：Ciliary Neuronotrophic Factor

CNTF 分子靶点综述

睫状神经营养因子 (CNTF) 在人类中是一种由睫状神经营养因子基因编码的蛋白质。人类 CNTF 是一个有 200 个氨基酸 (aa) 残基，分子量为 22.7 kDa 的单链多肽。该基因编码的蛋白质是 一种多肽激素，其作用仅限于在神经系统中促进神经递质的合成和某些神经元群的轴突生长。CNTF 是神经元和少突胶质细胞的有效生存因子，它可能与减少炎症性发作期间组织破坏有 关。目前已经证明 CNTF 还可以在骨表面细胞中表达，并能降低成骨细胞活性。

CNTF, ciliary neurotrophic factor 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CNTF 分子靶点信息

人 Human CNTF靶点分子功能（预测）

Enables growth factor activity and interleukin-6 receptor binding activity. Involved in ciliary neurotrophic factor-mediated signaling pathway; negative regulation of neuron apoptotic process; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within positive regulation of gene expression. Predicted to be located in extracellular region. Predicted to be active in axon and extracellular space. Implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Biomarker of keratoconus.

小鼠 Mouse Cntf 分子靶点信息

小鼠 Mouse Cntf 靶点分子功能（预测）

Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of photoreceptor cell differentiation; positive regulation of tyrosine phosphorylation of STAT protein; and regulation of retinal cell programmed cell death. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor).

大鼠 Rat Cntf 分子靶点信息

大鼠 Rat Cntf 靶点分子功能（预测）

Enables ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in several processes, including membrane hyperpolarization; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including axon; neuronal cell body; and plasma membrane bounded cell projection cytoplasm. Used to study Huntington's disease and glaucoma. Biomarker of hyperglycemia and retinitis pigmentosa. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor).

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