CHI3L1 靶点信息

CHI3L1 分子靶点信息概述

  • 分子名：CHI3L1, chitinase 3 like 1
  • 基因家族：Chitinases
  • 别名：GP39; YKL40; YK-40
  • 全称：cartilage glycoprotein-39; chitinase 3-like 1 (cartilage glycoprotein-39)

CHI3L1 分子靶点综述

几丁质酶3样蛋白1(CHI3L1)由多种类型细胞分泌，包括巨噬细胞、软骨细胞和某些肿瘤细胞。CHI3L1确切的生理功能还尚未知，但它参与了发育和炎性疾病，如哮喘和肿瘤。CHI3L1是促进Th2的细胞因子，在肿瘤患者的肿瘤微环境和血清中高水平表达。CHI3L1表达升高与多种类型肿瘤的发展阶段和结果强烈相关，说明CHI3L1可作为疾病严重程度的生物标志。在多形性成胶质细胞瘤的动物模型中，使用CHI3L1的中和抗体进行治疗是有效果的。CHI3L1可通过VEGF依赖和不依赖的途径促进血管发生。在γ放射下，CHI3L1也能增强肿瘤存活。

CHI3L1, chitinase 3 like 1 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CHI3L1 分子靶点信息

  • 分子名：CHI3L1, chitinase 3 like 1
  • 别称：
    • 39 kDa synovial protein
    • ASRT7
    • cartilage glycoprotein 39
    • CGP-39
    • chitinase 3-like 1 (cartilage glycoprotein-39)
    • chitinase-3-like protein 1
    • DKFZp686N19119
    • FLJ38139
    • GP-39
    • GP39
    • HC-gp39
    • hCGP-39
    • HCGP-3P
    • YK-40
    • YKL-40
    • YKL40
    • YYL-40
  • 基因序列：NCBI_Gene: 1116
  • 蛋白序列：UniProtKB: P36222

人 Human CHI3L1靶点分子功能（预测）

Enables chitin binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; response to interleukin-1; and response to interleukin-6. Located in extracellular space. Implicated in asthma and schizophrenia. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bone cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple).

小鼠 Mouse Chil1 分子靶点信息

小鼠 Mouse Chil1 靶点分子功能（预测）

Predicted to enable chitin binding activity. Involved in positive regulation of interleukin-8 production; positive regulation of protein kinase B signaling; and positive regulation of protein phosphorylation. Located in endoplasmic reticulum. Is expressed in alimentary system; limb; and skeleton. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1).

大鼠 Rat Chi3l1 分子靶点信息

  • 分子名：Chi3l1, chitinase 3 like 1
  • 别称：
    • cartilage glycoprotein 39
    • CGP-39
    • Chil1
    • chitinase 3-like 1
    • chitinase 3-like 1 (cartilage glycoprotein-39)
    • chitinase-3-like protein 1
    • GP-39
    • MGC109420
  • 基因序列：NCBI_Gene: 89824
  • 蛋白序列：

大鼠 Rat Chi3l1 靶点分子功能（预测）

Predicted to enable chitin binding activity. Involved in cellular response to interleukin-1; cellular response to tumor necrosis factor; and inflammatory response. Located in extracellular space. Biomarker of hypertension. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1).

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