CFD 靶点信息

CFD 分子靶点信息概述

  • 分子名：CFD, complement factor D
  • 基因家族：Granule associated serine proteases of immune defence; Complement system activation components
  • 别名：ADN
  • 曾用名：DF; PFD
  • 全称：adipsin; D component of complement (adipsin); properdin factor D; complement factor D (adipsin)

CFD 分子靶点综述

补体因子D，即D因子，又称脂肪酶，是一种丝氨酸蛋白酶，是激活补体旁路途经所必需的。D因子是胰蛋白酶家族的肽酶的成员，在人类中由CFD基因编码。D因子在多种组织中表达，包括单核细胞/巨噬细胞、肌肉、坐骨神经、子宫内膜、肾脏、肠道，尤其在脂肪细胞中高水平表达。在肾功能衰竭患者中，循环的D因子浓度升高。类似地，在范科尼综合征患者中，肾脏的近端肾小管功能受损，尿液D因子浓度也处于高水平。

CFD, complement factor D 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CFD 分子靶点信息

  • 分子名：CFD, complement factor D
  • 别称：
    • ADIPSIN
    • ADN
    • C3 convertase activator
    • complement factor D (adipsin)
    • complement factor D preproprotein
    • D component of complement (adipsin)
    • DF
    • PFD
    • properdin factor D
  • 基因序列：NCBI_Gene: 1675
  • 蛋白序列：UniProtKB: P00746

人 Human CFD靶点分子功能（预测）

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in complement activation. Predicted to act upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular exosome. Biomarker of obesity.

小鼠 Mouse Cfd 分子靶点信息

小鼠 Mouse Cfd 靶点分子功能（预测）

Predicted to enable endopeptidase activity. Acts upstream of or within several processes, including complement activation, alternative pathway; retina development in camera-type eye; and vascular associated smooth muscle cell differentiation. Located in extracellular space. Is expressed in adipose tissue; brown fat; epididymal fat pad; and white fat. Orthologous to human CFD (complement factor D).

大鼠 Rat Cfd 分子靶点信息

大鼠 Rat Cfd 靶点分子功能（预测）

Enables endopeptidase activity. Involved in Notch signaling pathway. Located in extracellular space. Used to study arthus reaction. Biomarker of obesity. Orthologous to human CFD (complement factor D).

CFD 分子产品列表

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