CD86 靶点信息

CD86 分子靶点信息概述

  • 分子名：CD86, CD86 molecule
  • 基因家族：CD molecules; V-set domain containing; B7 family
  • 别名：B7.2; B7-2
  • 曾用名：CD28LG2
  • 全称：B-lymphocyte antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)

CD86 分子靶点综述

CD86也称为B7.2，分子量80 kD，表达于树突状细胞、单核细胞、记忆T淋巴细胞、生发中心B淋巴细胞、活化B淋巴细胞以及活化T淋巴细胞。属于免疫球蛋白超家族，其配体是CD28和CD152 (CTLA4)。CD86与诱导剂CD28和抑制剂CTLA4相互作用，是诱导T淋巴细胞增殖及产生IL-2的主要协同因子。

CD86, CD86 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD86 分子靶点信息

  • 分子名：CD86, CD86 molecule
  • 别称：
    • activation B7-2 antigen
    • B-lymphocyte activation antigen B7-2
    • B-lymphocyte antigen B7-2
    • B7-2
    • B7-2 antigen
    • B7.2
    • B70
    • BU63
    • CD28 antigen ligand 2
    • CD28LG2
    • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
    • CTLA-4 counter-receptor B7.2
    • FUN-1
    • LAB72
    • MGC34413
    • T-lymphocyte activation antigen CD86
  • 基因序列：NCBI_Gene: 942
  • 蛋白序列：UniProtKB: P42081

人 Human CD86靶点分子功能（预测）

Predicted to enable signaling receptor activity. Predicted to be involved in several processes, including CD40 signaling pathway; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Predicted to act upstream of or within defense response to virus and toll-like receptor signaling pathway. Located in centriolar satellite; extracellular exosome; and plasma membrane. Implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Biomarker of several diseases, including autoimmune disease (multiple); cryoglobulinemia; hematologic cancer (multiple); lung disease (multiple); and pulmonary hypertension.

小鼠 Mouse Cd86 分子靶点信息

小鼠 Mouse Cd86 靶点分子功能（预测）

Predicted to enable signaling receptor binding activity. Involved in several processes, including CD40 signaling pathway; activation of phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; defense response to virus; and positive regulation of T cell proliferation. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).

大鼠 Rat Cd86 分子靶点信息

大鼠 Rat Cd86 靶点分子功能（预测）

Enables signaling receptor binding activity. Involved in several processes, including defense response to other organism; negative regulation of T cell anergy; and positive regulation of activated T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia and bronchiolitis obliterans. Biomarker of asthma; corneal disease; middle cerebral artery infarction; and orchitis. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule).

CD86 分子产品列表

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