CD59 靶点信息

CD59 分子靶点信息概述

  • 分子名：CD59, CD59 molecule (CD59 blood group)
  • 基因家族：Blood group antigens; CD molecules; LY6/PLAUR domain containing; Complement system regulators and receptors
  • 别名：16.3A5; EJ16; EJ30; EL32; G344; p18-20
  • 曾用名：MIC11; MIN1; MSK21; MIN2; MIN3
  • 全称：CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 antigen, complement regulatory protein; CD59 molecule, complement regulatory protein; CD59 molecule

CD59 分子靶点综述

CD59 也被称为保护素，在所有人类淋巴细胞、单核细胞、粒细胞和红细胞上均有表达。这种蛋白也在非造血细胞上表达，包括内皮细胞和神经元。CD59 与 CD2 相互作用，调节 T 细胞粘附，并在 T 细胞活化中发挥作用。最后，在系统性红斑狼疮(SLE)患者中观察到 CD55和 CD59 在人外周血细胞上的表达改变。

CD59, CD59 molecule (CD59 blood group) 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD59 分子靶点信息

  • 分子名：CD59, CD59 molecule (CD59 blood group)
  • 别称：
    • 16.3A5
    • 1F5
    • 1F5 antigen
    • 20 kDa homologous restriction factor
    • cd59 antigen
    • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
    • CD59 blood group antigen
    • CD59 glycoprotein
    • CD59 molecule
    • EJ16
    • EJ30
    • EL32
    • FLJ38134
    • FLJ92039
    • G344
    • HRF-20
    • HRF20
    • human leukocyte antigen MIC11
    • Ly-6-like protein
    • lymphocytic antigen CD59/MEM43
    • MAC-IP
    • MACIF
    • MEM43
    • MEM43 antigen
    • membrane attack complex (MAC) inhibition factor
    • membrane attack complex inhibition factor
    • membrane inhibitor of reactive lysis
    • MGC2354
    • MIC11
    • MIN1
    • MIN2
    • MIN3
    • MIRL
    • MSK21
    • p18-20
    • protectin
    • surface anitgen recognized by monoclonal antibody 16.3A5
    • T cell-activating protein
  • 基因序列：NCBI_Gene: 966
  • 蛋白序列：UniProtKB: P13987

人 Human CD59靶点分子功能（预测）

Predicted to enable complement binding activity. Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Located in cell surface. Is anchored component of external side of plasma membrane. Implicated in colorectal carcinoma and ovarian cancer. Biomarker of breast carcinoma; endometrial cancer; and ovarian cancer.

小鼠 Mouse Cd59a 分子靶点信息

小鼠 Mouse Cd59a 靶点分子功能（预测）

Predicted to enable complement binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of fibroblast growth factor production; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in external side of plasma membrane. Is expressed in several structures, including Meckel's cartilage; nervous system; neural retina; skeleton; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)).

大鼠 Rat Cd59 分子靶点信息

  • 分子名：Cd59, CD59 molecule
  • 别称：
    • Cb59b molecule
    • CD59 antigen
    • CD59 glycoprotein
    • CD59 molecule, complement regulatory protein
    • Cd59a
    • Cd59b
    • CD59b moleucle, complement regulatory protein
    • MAC-inhibitory protein
    • MAC-IP
    • MACIF
    • MACIP
    • membrane attack complex inhibition factor
    • protectin
  • 基因序列：NCBI_Gene: 25407
  • 蛋白序列：UniProtKB: P27274

大鼠 Rat Cd59 靶点分子功能（预测）

Enables complement binding activity. Involved in several processes, including negative regulation of activation of membrane attack complex; negative regulation of complement-dependent cytotoxicity; and positive regulation of T cell proliferation. Located in compact myelin; extracellular space; and sarcolemma. Used to study anterior uveitis; colorectal carcinoma; glomerulonephritis; nephrosis; and neuromyelitis optica. Biomarker of acute necrotizing pancreatitis; diabetic retinopathy; and myocardial infarction. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)).

CD59 分子产品列表

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