CD44 靶点信息

CD44 分子靶点信息概述

  • 分子名：CD44, CD44 molecule (Indian blood group)
  • 基因家族：Blood group antigens; CD molecules; Proteoglycans
  • 别名：IN; MC56; Pgp1; CD44R; HCELL; CSPG8
  • 曾用名：MIC4; MDU2; MDU3
  • 全称：hematopoietic cell E- and L-selectin ligand; chondroitin sulfate proteoglycan 8; CD44 antigen (homing function and Indian blood group system)

CD44 分子靶点综述

CD44为细胞表面的一种糖蛋白，参与细胞-细胞相互作用、细胞黏附和细胞迁移。CD44正常表达在所有的血细胞(血小板除外)和非造血组织，不表达在正常肝细胞，但表达在胆管上皮。CD44异常表达在多发性骨髓瘤细胞、大多数淋巴瘤、慢性淋巴细胞白血病、肿瘤性肥大细胞。CD44主要参与淋巴细胞的激活、参与细胞外基质中的透明质酸、层粘连蛋白等基质分子的结合、介导淋巴细胞与毛细血管后小静脉中的高柱状内皮细胞结合，使淋巴细胞穿过血管壁回到淋巴组织。

CD44, CD44 molecule (Indian blood group) 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD44 分子靶点信息

  • 分子名：CD44, CD44 molecule (Indian blood group)
  • 别称：
    • CD44 antigen
    • CDW44
    • cell surface glycoprotein CD44
    • chondroitin sulfate proteoglycan 8
    • CSPG8
    • ECMR-III
    • epican
    • extracellular matrix receptor III
    • GP90 lymphocyte homing/adhesion receptor
    • HCELL
    • hematopoietic cell E- and L-selectin ligand
    • heparan sulfate proteoglycan
    • Hermes antigen
    • homing function and Indian blood group system
    • HUTCH-I
    • hyaluronate receptor
    • IN
    • Indian blood group antigen
    • LHR
    • MC56
    • MDU2
    • MDU3
    • MGC10468
    • MIC4
    • MUTCH-I
    • Pgp1
    • phagocytic glycoprotein 1
    • soluble CD44
  • 基因序列：NCBI_Gene: 960
  • 蛋白序列：UniProtKB: P16070

人 Human CD44靶点分子功能（预测）

Enables hyaluronic acid binding activity. Contributes to cytokine receptor activity. Involved in several processes, including positive regulation of cell-cell adhesion; positive regulation of phosphorylation; and regulation of intracellular signal transduction. Located in several cellular components, including Golgi apparatus; apical plasma membrane; and lamellipodium membrane. Part of macrophage migration inhibitory factor receptor complex. Implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Biomarker of Krukenberg carcinoma; invasive ductal carcinoma; leiomyomatosis; lung adenocarcinoma; and urinary system cancer (multiple).

小鼠 Mouse Cd44 分子靶点信息

小鼠 Mouse Cd44 靶点分子功能（预测）

Enables hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)).

大鼠 Rat Cd44 分子靶点信息

大鼠 Rat Cd44 靶点分子功能（预测）

Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive regulation of neutrophil apoptotic process. Located in apical plasma membrane; basolateral plasma membrane; and nucleus. Part of protein-containing complex. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)).

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