CD36 靶点信息

CD36 分子靶点信息概述

  • 分子名：CD36, CD36 molecule
  • 基因家族：CD molecules; Scavenger receptors
  • 别名：SCARB3; GPIV; FAT; GP4; GP3B
  • 全称：CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor)

CD36 分子靶点综述

CD36 是一种 85kDa 的糖蛋白又称 GPIIIb 或 GPI，是胶原和血小板反应素等细胞外基质蛋白的受体。CD36 抗原在单核细胞、血小板、内皮细胞和一些人肿瘤细胞系上表达，但在淋巴细胞和粒细胞上不表达，它是红系分化的早期标志。已知 CD36 介导恶性疟原虫的粘附。CD36 抗体可诱导细胞脱颗粒、释放 ATP和 5-羟色胺、增加[Ca2+]ι,和酪氨酸磷酸化 130k Da 的底物蛋白。CD36 可与血小板反应素、长链脂肪酸、氧化 LDL、胶原 I 型、IV 型和 V 型以及凋亡细胞相结合。

CD36, CD36 molecule 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human CD36 分子靶点信息

  • 分子名：CD36, CD36 molecule
  • 别称：
    • BDPLT10
    • CD36 antigen (collagen type I receptor, thrombospondin receptor)
    • CD36 molecule (thrombospondin receptor)
    • CHDS7
    • cluster determinant 36
    • FAT
    • fatty acid translocase
    • glycoprotein IIIb
    • GP3B
    • GP4
    • GPIIIB
    • GPIV
    • leukocyte differentiation antigen CD36
    • PAS IV
    • PAS-4 protein
    • PASIV
    • platelet glycoprotein 4
    • platelet glycoprotein IV
    • SCARB3
    • scavenger receptor class B, member 3
  • 基因序列：NCBI_Gene: 948
  • 蛋白序列：UniProtKB: P16671

人 Human CD36靶点分子功能（预测）

Enables several functions, including amyloid-beta binding activity; fatty acid transmembrane transporter activity; and low-density lipoprotein particle binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; lipid transport; and second-messenger-mediated signaling. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Part of receptor complex. Implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); myeloid neoplasm (multiple); myositis (multiple); rheumatic heart disease; and sickle cell anemia.

小鼠 Mouse Cd36 分子靶点信息

小鼠 Mouse Cd36 靶点分子功能（预测）

Enables lipoprotein particle binding activity; lipoteichoic acid immune receptor activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including lipid transport; regulation of gene expression; and regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including phagocytosis; positive regulation of cytokine production; and response to bacterium. Located in several cellular components, including brush border membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including Meckel's cartilage; axial skeleton; bone; hindlimb; and telencephalon. Used to study platelet-type bleeding disorder 10. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule).

大鼠 Rat Cd36 分子靶点信息

  • 分子名：Cd36, CD36 molecule
  • 别称：
    • adipocyte membrane protein
    • CD36 antigen
    • CD36 antigen (collagen type I receptor, thrombospondin receptor)
    • Cd36 antigen-like
    • CD36 molecule (thrombospondin receptor)
    • collagen type I receptor thrombospondin receptor
    • Fat
    • fatty acid translocase
    • fatty acid transport protein
    • glycoprotein IIIb
    • GPIIIB
    • GPIV
    • LOC499984
    • MGC108510
    • MGC91634
    • PAS IV
    • PAS-4
    • platelet glycoprotein 4
    • platelet glycoprotein IV
    • RGD1562323
    • similar to fatty acid translocase/CD36
  • 基因序列：NCBI_Gene: 29184
  • 蛋白序列：

大鼠 Rat Cd36 靶点分子功能（预测）

Enables several functions, including oleic acid binding activity; scavenger receptor activity; and thrombospondin receptor activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule metabolic process; and response to peptide hormone. Located in several cellular components, including brush border membrane; caveola; and sarcolemma. Part of protein-containing complex. Used to study interstitial lung disease (multiple); macular degeneration; myocardial infarction; obesity; and polycystic ovary syndrome. Biomarker of artery disease (multiple); hypertrophic cardiomyopathy; nephrosis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule).

CD36 分子产品列表

CD36 分子靶点最新资讯

9月文献汇总 | 联科产品荣登《Nature》期刊，科研品质值得信赖！ 

新品发布 ▏深秋的第一波流式抗体，快来了解！