ICOS/CD278 靶点信息

ICOS/CD278 分子靶点信息概述

  • 分子名：ICOS, inducible T cell costimulator
  • 别名：AILIM; CD278
  • 全称：inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule

ICOS/CD278 分子靶点综述

CD278属于CD28和CTLA-4细胞表面受体家族，在活化的T细胞中高度表达。这对于T细胞和B细胞之间的有效相互作用，对T细胞依赖性抗原的正常抗体反应至关重要。它增强了所有基本的T细胞对外来抗原的反应，即增殖、淋巴因子的分泌、介导细胞间相互作用的分子的上调，以及对B细胞分泌抗体的有效帮助。

ICOS, inducible T cell costimulator 分子靶点种属信息

人 Human小鼠 Mouse大鼠 Rat

人 Human ICOS/CD278 分子靶点信息

  • 分子名：ICOS, inducible T cell costimulator
  • 别称：
    • activation-inducible lymphocyte immunomediatory molecule
    • AILIM
    • CD278
    • CVID1
    • inducible costimulator
    • inducible T-cell co-stimulator
    • inducible T-cell costimulator
    • MGC39850
  • 基因序列：NCBI_Gene: 29851
  • 蛋白序列：UniProtKB: Q9Y6W8

人 Human ICOS/CD278 靶点分子功能（预测）

Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency.

小鼠 Mouse Icos/CD278 分子靶点信息

小鼠 Icos/CD278 靶点分子功能（预测）

Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Located in external side of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator).

大鼠 Rat Icos/CD278 分子靶点信息

  • 分子名：Icos, inducible T-cell co-stimulator
  • 别称：
    • activation-inducible lymphocyte immunomediatory molecule
    • Ailim
    • inducible T-cell costimulator
  • 基因序列：NCBI_Gene: 287673
  • 蛋白序列：

大鼠 Rat Icos/CD278 靶点分子功能（预测）

Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator).

ICOS/CD278 分子产品列表

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