文章目录[隐藏]
CCN2 分子靶点信息概述
- 分子名:CCN2, cellular communication network factor 2
- 基因家族:Cellular communication network factors
- 别名:IGFBP8
- 曾用名:CTGF
- 全称:connective tissue growth factor
CCN2 分子靶点综述
结缔组织生长因子(CTGF)是CNN家族中的细胞基质蛋白。CTGF的胞外部分包括四个保守的、富含半胱氨酸的结构域:胰岛素样生长因子结合蛋白(IGFBP)结构域、血管性血友病C型重复序列(vWC)结构域、血小板反应蛋白1型重复序列(TSR)结构域以及含有半胱氨酸基元的C端结构域(CT)。CTGF在许多生物过程中发挥重要作用,包括细胞粘附、迁移、增殖、血管生成、骨骼发育和组织创伤修复。监测血清中CTGF水平可为一些病理情况如恶性肿瘤、糖尿病肾病、视网膜病变、纤维化、关节炎、胰腺癌和心血管疾病,提供更详细的见解。
CCN2, cellular communication network factor 2 分子靶点种属信息
人 Human CCN2 分子靶点信息
- 分子名:CCN2, cellular communication network factor 2
- 别称:
- CCN family member 2
- connective tissue growth factor
- CTGF
- HCS24
- hypertrophic chondrocyte-specific protein 24
- IBP-8
- IGF-binding protein 8
- IGFBP-8
- IGFBP8
- insulin-like growth factor-binding protein 8
- MGC102839
- NOV2
- 基因序列:NCBI_Gene: 1490
- 蛋白序列:UniProtKB: P29279
人 Human CCN2靶点分子功能(预测)
Enables protein C-terminus binding activity. Involved in positive regulation of MAPK cascade; positive regulation of cell differentiation; and positive regulation of stress fiber assembly. Colocalizes with collagen-containing extracellular matrix. Biomarker of ovarian cancer.
小鼠 Mouse Ccn2 分子靶点信息
- 分子名:Ccn2, cellular communication network factor 2
- 别称:
- connective tissue growth factor
- Ctgf
- fibroblast inducible secreted protein
- Fisp12
- Hcs24
- hypertrophic chondrocyte-specific gene product 24
- 基因序列:NCBI_Gene: 14219
- 蛋白序列:
小鼠 Mouse Ccn2 靶点分子功能(预测)
Enables heparin binding activity and integrin binding activity. Acts upstream of or within several processes, including cartilage condensation; cell surface receptor signaling pathway; and chondrocyte proliferation. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; sensory organ; and skeleton. Orthologous to human CCN2 (cellular communication network factor 2).
大鼠 Rat Ccn2 分子靶点信息
- 分子名:Ccn2, cellular communication network factor 2
- 别称:
- CCN family member 2
- connective tissue growth factor
- connective tissue growth-related protein
- Ctgf
- CTGRP
- 基因序列:NCBI_Gene: 64032
- 蛋白序列:
大鼠 Rat Ccn2 靶点分子功能(预测)
Enables fibronectin binding activity and growth factor activity. Involved in several processes, including positive regulation of G0 to G1 transition; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cell cortex; cis-Golgi network; and perinuclear region of cytoplasm. Used to study endomyocardial fibrosis. Biomarker of several diseases, including artery disease (multiple); lung disease (multiple); membranoproliferative glomerulonephritis; primary biliary cholangitis; and restrictive cardiomyopathy (multiple). Orthologous to human CCN2 (cellular communication network factor 2).
CCN2 分子产品列表
-
- EK198S
- ELISA标准品
Human CTGF Standard (人结缔组织生长因子 (CTGF) 标准品)
- ¥180.00
-
- EK198
- ELISA试剂盒
Human CTGF ELISA Kit检测试剂盒(酶联免疫吸附法)
- ¥1,600.00 – ¥2,650.00